Evidence map›Paper›PMID 31778741›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2020

Feedback-controlled photolytic gas phase nitric oxide delivery from S-nitrosothiol-doped silicone rubber films.

Gergely Lautner, Orsolya Lautner-Csorba, Blake Stringer, Mark E Meyerhoff, Steven P Schwendeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Development of a light-induced gas phase nitric oxide generator and its use in killing biofilm bacteria in vitro and ex vivo.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  3. Article
  4. Feasibility of controlled nitric oxide generationDalton transactions (Cambridge, England : 2003) · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gergely LautnerDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Orsolya Lautner-CsorbaDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Blake StringerDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Mark E MeyerhoffDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mmeyerho@umich.edu.
Steven P SchwendemanDepartment of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: schwende@umich.edu.

Funding

Controlled Photo-Release of Nitric Oxide for Antimicrobial Inhalation TherapyR21EB024038 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, STEVEN P. · 2017 to 2018
$427k
NIBIB NIH HHS R21 EB024038
6 · The paper itself

Abstract

Constant therapeutic gas phase nitric oxide (NO) delivery is achieved from S-nitrosothiol (RSNO) type NO donor doped silicone rubber films using feedback-controlled photolysis. For photo-release of the NO gas, the intensity of the LED light source is controlled via a PID (proportional-integral-derivative) controller implemented on a microcontroller. The NO concentration within the emitted gas phase is monitored continuously with a commercial amperometric NO gas sensor. NO release was accurately adjustable up to 10 ppm across a broad range of setpoints with response times of roughly 1 min or less. When NO is generated into an air recipient stream, lower NO yields and a comparable level of toxic nitrogen dioxide (NO

Indexed as

Nitric OxideS-NitrosothiolsFeedbackPhotolysisSilicone ElastomersNitric OxideSilicone ElastomersS-NitrosothiolsFeedback controlInhalation NO therapyNitric oxideNOS-nitrosothiol

Identifiers

PMID31778741
PMCPMC7895313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.