Evidence map›Paper›PMID 31778717›Full record

ArticleHormones and behavior2020

Prepubertal gonadectomy reveals sex differences in approach-avoidance behavior in adult mice.

Kristen Delevich, Christopher D Hall, David Piekarski, Yuting Zhang, Linda Wilbrecht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormones and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kristen DelevichDepartment of Psychology, University of California, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Christopher D HallDepartment of Psychology, University of California, Berkeley, CA 94720, USA.
David PiekarskiDepartment of Psychology, University of California, Berkeley, CA 94720, USA.
Yuting ZhangDepartment of Psychology, University of California, Berkeley, CA 94720, USA.
Linda WilbrechtDepartment of Psychology, University of California, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA. Electronic address: wilbrecht@berkeley.edu.
University of California, Berkeley · US

Funding

Corticostriatal circuits in behavioral flexibilityF32MH110184 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI DELEVICH, KRISTEN MARIE · 2016 to 2018
$171k
NIMH NIH HHS F32 MH110184
6 · The paper itself

Abstract

Adolescence is a developmental period that is associated with physical, cognitive, and affective maturation and a time when sex biases in multiple psychiatric diseases emerge. While puberty onset marks the initiation of adolescence, it is unclear whether the pubertal rise in gonadal hormones generates sex differences in approach-avoidance behaviors that may impact psychiatric vulnerability. To examine the influence of pubertal development on adult behavior, we removed the gonads or performed sham surgery in male and female mice just prior to puberty onset and assessed performance in an odor-guided foraging task and anxiety-related behaviors in adulthood. We observed no significant sex differences in foraging or anxiety-related behaviors between intact adult male and female mice but found significant differences between adult male and female mice that had been gonadectomized (GDX) prior to puberty onset. GDX males failed to acquire the odor-guided foraging task, showed reduced locomotion, and exhibited increased anxiety-like behavior, while GDX females showed the opposite pattern of behavior. These data suggest that puberty may minimize rather than drive differences in approach-avoidance phenotypes in male and female mice.

Indexed as

CastrationAnimalsAnxietyAvoidance LearningBehavior, AnimalCognitionExploratory BehaviorFemaleGonadal HormonesGrowth and DevelopmentLocomotionMaleMiceMice, Inbred C57BLSex CharacteristicsSexual MaturationGonadal HormonesApproach-avoidance behaviorForagingPubertySex differences

Identifiers

PMID31778717
PMCPMC12058001
OpenAlexW2991540460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.