ArticleCell2019
The Making of a Flight Feather: Bio-architectural Principles and Adaptation.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 60 citations in OpenAlex.
- Comparative Transcriptomics of Feather Follicles Reveals Potential Candidate Genes for Duck Feather Type Differentiation.Animals : an open access journal from MDPI · 2026Article
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Graded BMP signals modulate yellow and red color in fishes, impacting adult pigment patterns and conspecific shoaling behavior.Current biology : CB · 2026Article
- Graded BMP signals modulate yellow and red color in fishes impacting adult pigment pattern and behavior.bioRxiv : the preprint server for biology · 2025Article
- Feather-inspired janus interfaces with spatiotemporal ionic programming for diabetic wound infection control and regenerative healing.Materials today. Bio · 2025Article
- Sexually dimorphic sail feathers in the Mandarin duck as a model for lifelong developmental modulation.Scientific reports · 2025Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- New information on the Hind limb feathering, soft tissues and skeleton of Microraptor (Theropoda: Dromaeosauridae).BMC ecology and evolution · 2025Article
- The feather's multi-functional structure across nano to macro scales inspires hierarchical design.Journal of the Royal Society, Interface · 2025Review
- Wound-Induced Regeneration in Feather Follicles: A Stepwise Strategy to Regenerate Stem Cells.Journal of developmental biology · 2025Article
- Skin regional specification and higher-orderScience advances · 2025Article
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- The origin and early evolution of feathers: implications, uncertainties and future prospects.Biology letters · 2025Review
- Analysis of the Reliability of Feather Sections for Corticosterone Measurement in Pekin Ducks.Animals : an open access journal from MDPI · 2025Article
- Adaptive patterning of vascular network during avian skin development: Mesenchymal plasticity and dermal vasculogenesis.Cells & development · 2024Article
- Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers.Biology · 2024Article
- Conserved regulatory switches for the transition from natal down to juvenile feather in birds.Nature communications · 2024Article
- Spatial patterning of energy metabolism during tissue morphogenesis.Current opinion in cell biology · 2023Review
- Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.Chinese journal of physics · 2023Article
- Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves.Research square · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 10 institutions in 3 countries.
Funding
Abstract
The evolution of flight in feathered dinosaurs and early birds over millions of years required flight feathers whose architecture features hierarchical branches. While barb-based feather forms were investigated, feather shafts and vanes are understudied. Here, we take a multi-disciplinary approach to study their molecular control and bio-architectural organizations. In rachidial ridges, epidermal progenitors generate cortex and medullary keratinocytes, guided by Bmp and transforming growth factor β (TGF-β) signaling that convert rachides into adaptable bilayer composite beams. In barb ridges, epidermal progenitors generate cylindrical, plate-, or hooklet-shaped barbule cells that form fluffy branches or pennaceous vanes, mediated by asymmetric cell junction and keratin expression. Transcriptome analyses and functional studies show anterior-posterior Wnt2b signaling within the dermal papilla controls barbule cell fates with spatiotemporal collinearity. Quantitative bio-physical analyses of feathers from birds with different flight characteristics and feathers in Burmese amber reveal how multi-dimensional functionality can be achieved and may inspire future composite material designs. VIDEO ABSTRACT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.