ArticleCell2019
Modeling the Evolution of Human Brain Development Using Organoids.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Deciphering the role of structural variation in human evolution: a functional perspective.Current opinion in genetics & development · 2024Review
- Current advances in primate genomics: novel approaches for understanding evolution and disease.Nature reviews. Genetics · 2023Review
- Forebrain Organoids to Model the Cell Biology of Basal Radial Glia in Neurodevelopmental Disorders and Brain Evolution.Frontiers in cell and developmental biology · 2022Review
- A Brain Region-Specific Expression Profile for Genes Within Large Introgression Deserts and Under Positive Selection inFrontiers in cell and developmental biology · 2022Article
- Evolutionary Changes in Pathways and Networks of Genes Expressed in the Brains of Humans and Macaques.Journal of molecular neuroscience : MN · 2021Article
- Article
- Behavior and lineage progression of neural progenitors in the mammalian cortex.Current opinion in neurobiology · 2021Review
- Evolutionary conservation and divergence of the human brain transcriptome.Genome biology · 2021Article
- Multiscale 3D phenotyping of human cerebral organoids.Scientific reports · 2020Article
- Uncovering cell biology in the third dimension.Molecular biology of the cell · 2020Article
- Role ofFrontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In a recent issue of Nature, Kanton et al. explore human brain evolution and development by profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chimpanzee, and macaque stem cells. Their results reveal key molecular characteristics that differentiate humans and non-human primates at the earliest stages of brain development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.