Evidence map›Paper›PMID 31778581›Full record

ReviewImmunology2020

Transcriptomic immune profiles of human flavivirus-specific T-cell responses.

Alba Grifoni, Yuan Tian, Alessandro Sette, Daniela Weiskopf

Open access · greenAbstract readReview
In one paragraph

Review in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alba GrifoniDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-2209-5966
Yuan TianDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
Daniela WeiskopfDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
La Jolla Institute for Immunology · US

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Bjoern Peters · 2015 to 2026
$36.7M
NIAID NIH HHS HHSN272200900042CNIAID NIH HHS U19 AI118626NIH HHS HHSN27220140045C
6 · The paper itself

Abstract

The Flavivirus genus of viruses includes dengue (DENV), Zika (ZIKV), yellow fever (YFV), Japanese encephalitis (JEV), and West Nile (WNV) viruses. Infections with these species combined are prevalent in tropical and sub-tropical areas, affecting millions of people and ranging from asymptomatic to severe forms of the disease. They therefore pose a serious threat to global public health. Several studies imply a role for T cells in the protection but also pathogenesis against the different flavivirus species. Identifying flavivirus-specific T-cell immune profiles and determining how pre-exposure of one species might affect the immune response against subsequent infections from other species is important to further define the role of T cells in the immune response against infection. Understanding the immune profiles of the flavivirus-specific T-cell response in natural infection is important to understand the T-cell response in the context of vaccination. In this review, we summarize the current knowledge on human immune profiles of flavivirus-specific T-cell reactivity, comparing natural infection with the acute form of the disease and vaccination in different flavivirus infections.

Indexed as

Cross ReactionsFlavivirusFlavivirus InfectionsGene Expression ProfilingHost Microbial InteractionsHumansImmunity, CellularImmunogenicity, VaccineSeverity of Illness IndexT-LymphocytesTranscriptomeViral VaccinesViral VaccinesDengue virusT cellstranscriptomicyellow fever virusZika virus

Identifiers

PMID31778581
PMCPMC7160650
OpenAlexW2990423768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.