Evidence map›Paper›PMID 31778355›Full record

ArticleMicrobial genomics2019

A guide to machine learning for bacterial host attribution using genome sequence data.

Nadejda Lupolova, Samantha J Lycett, David L Gally

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Predicting clinical outcome ofMicrobial genomics · 2025
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  9. Predictive phage therapy forProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
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  19. Pathogenic potential assessment of the Shiga toxin-producingProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nadejda LupolovaDivision of Infection and Immunity, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh, EH25 9RG, UK.
Samantha J LycettDivision of Infection and Immunity, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh, EH25 9RG, UK.
David L GallyDivision of Infection and Immunity, The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh, EH25 9RG, UK.
Roslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/P02095X/1
6 · The paper itself

Abstract

With the ever-expanding number of available sequences from bacterial genomes, and the expectation that this data type will be the primary one generated from both diagnostic and research laboratories for the foreseeable future, then there is both an opportunity and a need to evaluate how effectively computational approaches can be used within bacterial genomics to predict and understand complex phenotypes, such as pathogenic potential and host source. This article applied various quantitative methods such as diversity indexes, pangenome-wide association studies (GWAS) and dimensionality reduction techniques to better understand the data and then compared how well unsupervised and supervised machine learning (ML) methods could predict the source host of the isolates. The study uses the example of the pangenomes of 1203

Indexed as

Host SpecificityMachine LearningAnimalsBirdsCattleGenome, BacterialGenome-Wide Association StudyHumansSalmonella InfectionsSalmonella Infections, AnimalSalmonella typhimuriumSwineWhole Genome Sequencinghost attributionhost specificitymachine learningSalmonellawhole-genome sequences

Identifiers

PMID31778355
PMCPMC6939162
OpenAlexW2991470468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.