Evidence map›Paper›PMID 31778282›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2020

In-field evaluation of Xpert® HCV viral load Fingerstick assay in people who inject drugs in Tanzania.

Zameer Mohamed, Jessie Mbwambo, John Rwegasha, Nicodem Mgina, Basra Doulla, Promise Mwakale, Edouard Tuaillon, Stephane Chevaliez, Yusuke Shimakawa, Simon D Taylor-Robinson and 3 more

Abstract read
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Five Years of HCV Dried Blood Spot Testing in At-Risk Populations and the Impact of Reduced Sensitivity on Missed Diagnoses.Liver international : official journal of the International Association for the Study of the Liver · 2026
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  20. In-field evaluation of Xpert® HCV viral load Fingerstick assay in people who inject drugs in Tanzania.Liver international : official journal of the International Association for the Study of the Liver · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zameer MohamedDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.ORCID 0000-0002-3713-0277
Jessie MbwamboDepartment of Psychiatry, Muhimbili National Hospital, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
John RwegashaDepartment of Gastroenterology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Nicodem MginaTanzania Central Tuberculosis Reference Laboratory, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Basra DoullaTanzania Central Tuberculosis Reference Laboratory, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Promise MwakaleDepartment of Bioethics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Edouard TuaillonINSERM U 1058, Université Montpellier 1, Montpellier, France.
Stephane ChevaliezDepartment of Virology, French National Reference Center for Viral Hepatitis B, C and Delta, Hopital Henri Mondor, Université Paris-Est, Créteil, France.
Yusuke ShimakawaUnité d'Épidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France.
Simon D Taylor-RobinsonDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Mark R ThurszDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Ashley S BrownDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.
Maud LemoineDepartment of Hepatology, Imperial College London, St Mary's Hospital, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundAlthough novel hepatitis C virus (HCV) RNA point-of-care technology has the potential to enhance the diagnosis in resource-limited settings, very little real-world validation of their utility exists. We evaluate the performance of HCV RNA quantification using the Xpert

methodsBetween December 2018 and February 2019, consecutive HCV seropositive PWID attending the OAT clinic provided paired venous and Fingerstick samples for HCV RNA quantification. These were processed onsite using the GeneXpert

resultsA total of 208 out of 220 anti-HCV-positive participants recruited (94.5%) had a valid Xpert

conclusionThis study found excellent performance of the Xpert

Indexed as

Hepatitis CPharmaceutical PreparationsHepacivirusHumansRNA, ViralSensitivity and SpecificityTanzaniaViral LoadPharmaceutical PreparationsRNA, Viralhepatitis C viurs (HCV) diagnosispeople who inject drugs (PWID)point-of-care (POC)sub-Saharan AfricaXpert

Identifiers

PMID31778282
PMCPMC7079170

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.