Evidence map›Paper›PMID 31778279›Full record

ArticleCancer science2020

miR-30e-5p represses angiogenesis and metastasis by directly targeting AEG-1 in squamous cell carcinoma of the head and neck.

Shuiting Zhang, Guo Li, Chao Liu, Shanhong Lu, Qiancheng Jing, Xiyu Chen, Hua Zheng, Huiling Ma, Diekuo Zhang, Shuling Ren and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
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  14. Identification of Tumor-SuppressiveInternational journal of molecular sciences · 2022
    Article
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  17. Review
  18. Review
  19. Article
  20. Regulation of angiogenesis by microRNAs in cancer.Molecular medicine reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Shuiting ZhangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Guo LiDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Chao LiuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Shanhong LuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Qiancheng JingDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Xiyu ChenDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Hua ZhengDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Huiling MaDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Diekuo ZhangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Shuling RenDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Zhe ShenDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yunyun WangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Zhaoyi LuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Donghai HuangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Pingqing TanDepartment of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, China.
Jie ChenDepartment of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, China.
Xin ZhangDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yuanzheng QiuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Yong LiuDepartment of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0001-5102-0309
Central South University · CN

Funding

Fundamental Research Funds for the Central South University 1053320182447Huxiang Young Talent Project 2018RS3024National Key Research and Development Program of China 2016YFC0902003National Natural Science Foundation of China 81874133, 81773243, 81772903, 81602684, 81974424Natural Science Foundation of Hunan Province 2017JJ3488Natural Science Foundation of Hunan Province 2018JJ2630Natural Science Foundation of Hunan Province 2019JJ40481Natural Science Foundation of Hunan Province 2019JJ50944Xiangya Hospital-Sinobioway Clinic and Rehabilitation Research Foundation XYWM2015123
6 · The paper itself

Abstract

Metastasis is a critical determinant for the treatment strategy and prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). However, the mechanisms underlying SCCHN metastasis are poorly understood. Our study sought to determine the key microRNA and their functional mechanisms involved in SCCHN metastasis. For The Cancer Genome Atlas (TCGA) data analysis, quantitative PCR was used to quantify the level of miR-30e-5p in SCCHN and its clinical significance was further analyzed. A series of in vitro and in vivo experiments were applied to determine the effects of miR-30e-5p and its target AEG-1 on SCCHN metastasis. A mechanism investigation further revealed that AEG-1 was implicated in the angiogenesis and metastasis mediated by miR-30e-5p. Overall, our study confirms that miR-30e-5p is a valuable predictive biomarker and potential therapeutic target in SCCHN metastasis.

Indexed as

AnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansLung NeoplasmsMaleMembrane ProteinsMiceMicroRNAsNeoplasm TransplantationNeovascularization, PathologicPrognosisRNA-Binding ProteinsMembrane ProteinsMicroRNAsMIRN30b microRNA, humanMTDH protein, humanRNA-Binding ProteinsAEG-1angiogenesismetastasismiR-30e-5psquamous cell carcinoma of the head and neck

Identifiers

PMID31778279
PMCPMC7004514
OpenAlexW2991132013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.