Evidence map›Paper›PMID 31778245›Full record

ArticleStem cells (Dayton, Ohio)2020

Effects of thyroid hormone on mitochondria and metabolism of human preimplantation embryos.

Laila Noli, Shirin E Khorsandi, Angela Pyle, Gnanaratnam Giritharan, Norah Fogarty, Antonio Capalbo, Liani Devito, Vladimir M Jovanovic, Preeti Khurana, Hannah Rosa and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Stem cells (Dayton, Ohio), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 6 countries.

Laila NoliDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.
Shirin E KhorsandiInstitute of Liver Studies, King's College Hospital, London, UK.
Angela PyleWellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Gnanaratnam GiritharanNevada Center for Reproductive Medicine, Reno, Nevada.
Norah FogartyHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK.
Antonio CapalboIgenomix Italy, via Fermi 1, Marostica, Italy.
Liani DevitoDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.
Vladimir M JovanovicBioinformatics Solution Center and Human Biology Group; Institute for Zoology; Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Berlin, Germany.
Preeti KhuranaDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.
Hannah RosaMitoDNA Service Lab, King's College London, London, UK.
Nikola KolundzicDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.
Aleksandra CvoroCenter for Bioenergetics, Houston Methodist Research Institute, Houston, Texas.
Kathy K NiakanHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK.
Afshan MalikMitoDNA Service Lab, King's College London, London, UK.
Russell FoulkNevada Center for Reproductive Medicine, Reno, Nevada.
Nigel HeatonInstitute of Liver Studies, King's College Hospital, London, UK.
Mohammad Saleh ArdawiDepartment of Pathological Sciences, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia.
Patrick F ChinneryMRC-Mitochondrial Biology Unit and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Caroline OgilvieDepartment of Medical and Molecular Genetics, King's College London, London, UK.
Yacoub KhalafDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.
Dusko IlicDivision of Women's and Children's Health, Faculty of Life Sciences and Medicine, King's College London and Assisted Conception Unit, Guy's Hospital, London, UK.ORCID 0000-0003-1647-0026
Guy's Hospital · GBKing's College London · GBKing's College Hospital · GBThe Francis Crick Institute · GBHouston Methodist · USIgenomix · ITInstitute of Zoology · KZSoliman Fakeeh Hospital · SAUniversity of Cambridge · GBWellcome Centre for Mitochondrial Research · GB

Funding

Cancer Research UK FC001120Medical Research Council MC_UP_1202/9Wellcome Trust FC001120
6 · The paper itself

Abstract

Thyroid hormones are regarded as the major controllers of metabolic rate and oxygen consumption in mammals. Although it has been demonstrated that thyroid hormone supplementation improves bovine embryo development in vitro, the cellular mechanisms underlying these effects are so far unknown. In this study, we investigated the role of thyroid hormone in development of human preimplantation embryos. Embryos were cultured in the presence or absence of 10

Indexed as

BlastocystFemaleHumansMitochondriaOxidative PhosphorylationPregnancyThyroid HormonesThyroid Hormonesembryo developmentmitochondriaoxidative phosphorylationT3thyroid hormone

Identifiers

PMID31778245
PMCPMC7064942
OpenAlexW2990995980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.