Evidence map›Paper›PMID 31778174›Full record

ArticleMolecular biology and evolution2020

Genetic Landscapes Reveal How Human Genetic Diversity Aligns with Geography.

Benjamin M Peter, Desislava Petkova, John Novembre

Abstract read
In one paragraph

Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Estimating human mobility in Holocene Western Eurasia with large-scale ancient genomic data.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Pooled it
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  6. Evolutionary Influences on Local Patterns of Genetic Relatedness.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benjamin M PeterDepartment of Human Genetics, University of Chicago, Chicago, IL.
Desislava PetkovaWellcome Trust Center for Human Genetics, University of Oxford, Oxford, United Kingdom.
John NovembreDepartment of Human Genetics, University of Chicago, Chicago, IL.

Funding

Population Genetic Consequences of Recent Explosive Population Growth in HumansR01GM108805 · NIGMS · CORNELL UNIVERSITY · PI CLARK, ANDREW G, KEINAN, ALON · 2014 to 2017
$2.2M
Extending Tools for Visualization of Geographic Structure in Population Genomic DataR01GM132383 · NIGMS · UNIVERSITY OF CHICAGO · PI NOVEMBRE, JOHN · 2019 to 2022
$1.4M
Tools for Visualization of Geographic Structure in Population Genomic DataU01CA198933 · NCI · UNIVERSITY OF CHICAGO · PI NOVEMBRE, JOHN · 2015 to 2017
$1.2M
NCI NIH HHS U01 CA198933NIGMS NIH HHS R01 GM108805NIGMS NIH HHS R01 GM132383
6 · The paper itself

Abstract

Geographic patterns in human genetic diversity carry footprints of population history and provide insights for genetic medicine and its application across human populations. Summarizing and visually representing these patterns of diversity has been a persistent goal for human geneticists, and has revealed that genetic differentiation is frequently correlated with geographic distance. However, most analytical methods to represent population structure do not incorporate geography directly, and it must be considered post hoc alongside a visual summary of the genetic structure. Here, we estimate "effective migration" surfaces to visualize how human genetic diversity is geographically structured. The results reveal local patterns of differentiation in detail and emphasize that while genetic similarity generally decays with geographic distance, the relationship is often subtly distorted. Overall, the visualizations provide a new perspective on genetics and geography in humans and insight to the geographic distribution of human genetic variation.

Indexed as

Genetic VariationHuman MigrationGeographyHuman GeneticsHumansgeographic structuregeographyhuman geneticsisolation-by-distancepopulation geneticspopulation structure

Identifiers

PMID31778174
PMCPMC7086171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.