ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2020
Distal esophagus is the most commonly involved site for strictures in patients with eosinophilic esophagitis.
Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis.Alimentary pharmacology & therapeutics · 2025Pooled it
- Pooled it
- Mast cells infiltrates are common in eosinophilic esophagitis and still elevated in histological remission: A digital evaluation in children.Journal of pediatric gastroenterology and nutrition · 2025Article
- An Esophageal Luminal Diameter of 16 mm Predicts Dysphagia Resolution in Eosinophilic Esophagitis.Digestive diseases and sciences · 2025Article
- Tissue-specific inducible IL-33 expression elicits features of eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2024Article
- Histological Phenotyping in Eosinophilic Esophagitis: Localized Proximal Disease Is Infrequent but Associated with Less Severe Disease and Better Disease Outcome.International archives of allergy and immunology · 2024Article
- Formulations of Topical Steroids in Eosinophilic Esophagitis-Current Treatment and Emerging Possibilities.Journal of clinical medicine · 2022Review
- Optimizing the Endoscopic Examination in Eosinophilic Esophagitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Obesity reduces the requirement for subsequent esophageal stricture dilation in adults with eosinophilic esophagitis.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Clinical features and time trends associated with an endoscopically normal esophagus in active eosinophilic esophagitis.Endoscopy · 2021Article
- Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Article
- Acquired Esophageal Strictures in Children: Morphometric and Immunohistochemical Analyses.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyArticle
- Clinical Presentation of EoE in Adults: A Characteristic Story!?Inflammatory intestinal diseasesReview
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Abstract
While strictures are common in eosinophilic esophagitis (EoE), there are few data on stricture distribution and characteristics. Our primary aim was to characterize strictures by location in the esophagus in EoE and associated clinical, endoscopic, and histologic features. This was a retrospective study from the UNC EoE Clinicopathologic Database of subjects with esophageal strictures or narrowing from 2002 to 2017. Strictures were categorized as distal esophagus/gastroesophageal junction, mid-esophagus, proximal esophagus, or diffusely narrowed. Stricture location was assessed and compared with clinical, endoscopic, and histologic features, and also with treatment response to diet or topical steroids. Efficacy of combination therapy with dilation and intralesional steroid injection was assessed in a sub-group of patients with strictures. Of 776 EoE cases, 219 (28%) had strictures, 45% of which were distal, 30% were proximal, 5% were mid-esophageal, and 20% had diffuse narrowing. Those with mid-esophageal strictures were younger (P = 0.02) and had shorter symptom duration (P < 0.01). Those with diffuse esophageal narrowing were more likely to be women (57%) and have abdominal pain (25%). There was no association between other clinical, endoscopic, and histologic findings and treatment response based on stricture location. Fourteen patients (8%) received intralesional triamcinolone injection and subsequently achieved a higher mean dilation diameter after injection (13.7 vs. 15.5 mm; P < 0.01). In conclusion, almost half of strictures in EoE patients were in the distal esophagus. Therefore, EoE should be a diagnostic consideration in patients with focal distal strictures and not presumed to be secondary to gastroesophageal reflux disease.
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