Evidence map›Paper›PMID 31778043›Full record

ArticleAdvanced healthcare materials2020

Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair.

Jeffrey J D Henry, Lawrence Delrosario, Jun Fang, Sze Yue Wong, Qizhi Fang, Richard Sievers, Surya Kotha, Aijun Wang, Diana Farmer, Praneeth Janaswamy and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Jeffrey J D HenryDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Lawrence DelrosarioDepartment of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA.
Jun FangDepartment of Bioengineering and Medicine, University of California, Los Angeles, CA, 90095, USA.ORCID 0000-0002-8435-330X
Sze Yue WongDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Qizhi FangDepartment of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA.
Richard SieversDepartment of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA.
Surya KothaDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
Aijun WangDepartment of Surgery, University of California, Davis, CA, 95817, USA.
Diana FarmerDepartment of Surgery, University of California, Davis, CA, 95817, USA.
Praneeth JanaswamyDepartment of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA.
Randall J LeeDepartment of Medicine, Cardiovascular Research Institute and Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA.
Song LiDepartment of Bioengineering, University of California, Berkeley, CA, 94720, USA.
University of California, San Francisco · USUniversity of California, Berkeley · USUniversity of California, Davis · USUniversity of California, Los Angeles · US

Funding

In Situ Regeneration of Blood VesselR01HL121450 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2015 to 2018
$1.8M
Stem Cells in Vascular RemodelingR01HL117213 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2013 to 2016
$1.4M
Development of nanofibrous vascular grafts with efficent angiogenic potentialF31HL094162 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HENRY, JEFFREY JUSTIN DAVID · 2008 to 2012
$123k
NHLBI NIH HHS F31 HL094162NHLBI NIH HHS R01 HL117213NHLBI NIH HHS R01 HL121450
6 · The paper itself

Abstract

Ischemic heart disease represents the leading cause of death worldwide. Heart failure following myocardial infarction (MI) is associated with severe fibrosis formation and cardiac remodeling. Recently, injectable hydrogels have emerged as a promising approach to repair the infarcted heart and improve heart function through minimally invasive administration. Here, a novel injectable human amniotic membrane (hAM) matrix is developed to enhance cardiac regeneration following MI. Human amniotic membrane is isolated from human placenta and engineered to be a thermoresponsive, injectable gel around body temperature. Ultrasound-guided injection of hAM matrix into rat MI hearts significantly improves cardiac contractility, as measured by ejection fraction (EF), and decrease fibrosis. The results of this study demonstrate the feasibility of engineering as an injectable hAM matrix and its efficacy in attenuating degenerative changes in cardiac function following MI, which may have broad applications in tissue regeneration.

Indexed as

AmnionAnimalsCardiotonic AgentsCattleCells, CulturedCollagenEpithelial CellsExtracellular MatrixFemaleFibrosisGlycosaminoglycansHumansHydrogelsInjectionsMaterials TestingMyocardial InfarctionCardiotonic AgentsCollagenGlycosaminoglycansHydrogelsamniotic membranesdecellularizationhydrogelsmyocardial infarctions

Identifiers

PMID31778043
PMCPMC6986802
OpenAlexW2990934775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.