Evidence map›Paper›PMID 31778004›Full record

ArticleHaemophilia : the official journal of the World Federation of Hemophilia2020

Excessive breakthrough bleeding in haemophilia B patients on factor IX-albumin fusion protein prophylactic therapy: A single centre case series.

Brendan Kleiboer, Brenda Nielsen, Alica D Ma, Yasmina Abajas, Dougald M Monroe, Nigel S Key

Open access · greenAbstract readCase ReportsLetter
In one paragraph

Article in Haemophilia : the official journal of the World Federation of Hemophilia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Extended Half-Life Factor Concentrates in Haemophilia Treatment.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  2. Review
  3. Extravascular factor IX after gene therapy in hemophilia B, does it matter?Research and practice in thrombosis and haemostasis · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. How do we optimally utilize factor concentrates in persons with hemophilia?Hematology. American Society of Hematology. Education Program · 2021
    Review
  8. Optimal trough levels in haemophilia B: Raising expectations.Haemophilia : the official journal of the World Federation of Hemophilia · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brendan KleiboerDepartment of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0001-7334-4822
Brenda NielsenHemophilia and Thrombosis Center, University of North Carolina, Chapel Hill, NC, USA.
Alica D MaHemophilia and Thrombosis Center, University of North Carolina, Chapel Hill, NC, USA.
Yasmina AbajasDepartment of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
Dougald M MonroeDepartment of Medicine, University of North Carolina, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-0493-2943
Nigel S KeyHemophilia and Thrombosis Center, University of North Carolina, Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-8930-4304
University of North Carolina at Chapel Hill · US

Funding

Research Training in Hematology at UNC Chapel HillT32HL007149 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nigel S. Key · 1985 to 2026
$8.6M
NHLBI NIH HHS T32 HL007149NIH HHS T32 HL007149
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedFactor IXHemophilia BHemorrhageHumansMaleMiddle AgedFactor IX

Identifiers

PMID31778004
PMCPMC6992514
OpenAlexW2990594927

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.