ArticleHuman brain mapping2020
White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Transferability and sustainability of process-based multi-task adaptive cognitive training in community-dwelling older adults with mild cognitive impairment: a randomized controlled trial.BMC psychiatry · 2023Trial
- White matterAlzheimer's research & therapy · 2026Article
- Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging.Quantitative imaging in medicine and surgery · 2026Article
- Correlation between white matter lesions and cognitive impairment after stroke.European journal of medical research · 2025Article
- Long-Term Post-Stroke Cognition in Patients With Minor Ischemic Stroke is Related to Tract-Based Disconnection Induced by White Matter Hyperintensities.Human brain mapping · 2025Article
- White matter hyperintensities drive propagating grey matter atrophy in cerebral small vessel disease.Brain communications · 2025Article
- Distributed associations among white matter hyperintensities and structural brain networks with fluid cognition in healthy aging.Cognitive, affective & behavioral neuroscience · 2024Article
- The Influence of Structural Brain Changes on Cognition in the Context of Healthy Aging: Exploring Mediation Effects Through gBAT-The Graphical Brain Association Tool.Human brain mapping · 2024Article
- Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease.Children (Basel, Switzerland) · 2024Article
- Correspondence between white matter hyperintensities and regional grey matter volumes in Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Frailty and Processing Speed Performance at the Cusp of Midlife in CATSLife.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.Neurology · 2023Article
- Cortical thickness, gray matter volume, and cognitive performance: a crosssectional study of the moderating effects of age on their interrelationships.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- COVID-19 severity is related to poor executive function in people with post-COVID conditions.Journal of neurology · 2023Article
- Article
- Adulthood cognitive trajectories over 26 years and brain health at 70 years of age: findings from the 1946 British Birth Cohort.Neurobiology of aging · 2023Article
- Detecting conversion from mild cognitive impairment to Alzheimer's disease using FLAIR MRI biomarkers.NeuroImage. Clinical · 2023Article
- White matter integrity mediates the associations between white matter hyperintensities and cognitive function in patients with silent cerebrovascular diseases.CNS neuroscience & therapeutics · 2023Article
- The Influence of Processing Speed, Attention, and Inhibition on Texas Functional Living Scale Performance.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022Article
- Pulmonary function is associated with cognitive decline and structural brain differences.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship between cerebral patterns of GMv and cognition in 521 (mean age 57.7 years) cognitively unimpaired middle-aged individuals. Episodic memory (EM) was measured with the Memory Binding Test and executive functions (EF) using five WAIS-IV subtests. WMH were automatically determined from T2 and FLAIR sequences and characterized using diffusion-weighted imaging (DWI) parameters. WMH volume was entered as a mediator in a voxel-wise mediation analysis relating GMv and cognitive performance (with both EM and EF composites and the individual tests independently). The mediation model was corrected by age, sex, education, number of Apolipoprotein E (APOE)-ε4 alleles and total intracranial volume. We found that even at very low levels of WMH burden in the cohort (median volume of 3.2 mL), higher WMH lesion volume was significantly associated with a widespread pattern of lower GMv in temporal, frontal, and cerebellar areas. WMH mediated the relationship between GMv and EF, mainly driven by processing speed, but not EM. DWI parameters in these lesions were compatible with incipient demyelination and axonal loss. These findings lead to the reflection on the relevance of the control of cardiovascular risk factors in middle-aged individuals as a valuable preventive strategy to reduce or delay cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.