Evidence map›Paper›PMID 31777948›Full record

ReviewFEBS letters2019

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host.

Silvio Hemmi, Katherine R Spindler

Open access · bronzeAbstract readReview
In one paragraph

Review in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Silvio HemmiInstitute of Molecular Life Sciences, University of Zürich, Switzerland.ORCID 0000-0002-4238-2217
Katherine R SpindlerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9829-6051
University of Michigan · USUniversity of Zurich · CH

Funding

Viral interaction with host eIF2alpha kinasesR01AI133935 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2018 to 2022
$3.0M
NIAID NIH HHS R01 AI133935Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A_146286
6 · The paper itself

Abstract

Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.

Indexed as

Adenoviridae InfectionsAnimalsGene Expression Regulation, ViralHost-Pathogen InteractionsMastadenovirusMiceSpecies SpecificityViral ProteinsViral TropismViral Proteinsadenovirus vaccinesadenovirus vectorsalpha-defensinshost susceptibility to virusesimmunoproteasomeLy6mouse adenovirusPKRviral pathogenesis

Identifiers

PMID31777948
PMCPMC6928396
OpenAlexW2989747450

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.