ArticleFrontiers in dentistry
Effects of Amoxicillin on the Structure and Mineralization of Dental Enamel and Dentin in Wistar Rats.
Article in Frontiers in dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Effects of Antibiotics and Anti-Inflammatory Drugs on Enamel Development: A Systematic Review with Quantitative Synthesis.International dental journal · 2026Pooled it
- Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks.Clinical and experimental dental research · 2025Article
- Effects of maternal morphine consumption on odontogenesis in rats: A histomorphometric study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Highlighting the Role of Prenatally Administered Drugs in the Production of Dental Enamel Defects in Rats by Polarized Light Microscopy.Biomedicines · 2025Article
- Evaluation of the Effects of Amoxicillin on Tooth Development in Rats by Histological and Histomorphometric Study.Archives of Razi Institute · 2023Article
- Applications of Optical Coherence Tomography in the Diagnosis of Enamel Defects.Diagnostics (Basel, Switzerland) · 2022Article
- In vivo effect of fluoride combined with amoxicillin on enamel development in rats.Journal of applied oral science : revista FOB · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe development of teeth is affected by genetic and environmental factors. Amoxicillin is a widely prescribed semi-synthetic antibiotic. Its most frequent side effects are gastrointestinal disorders and hypersensitivity reactions. The purpose of this study was to determine the effect produced by amoxicillin administration on dental enamel and dentin in Wistar rats. MATERIALS AND
methodsTwelve pregnant adult Wistar rats were equally divided into four different groups. Negative controls were prescribed with a saline solution. Positive controls were prescribed with tetracycline (130 mg/kg). The other two groups were treated with amoxicillin doses of 50 and 100 mg/kg (every 8 hours), respectively. The treatments were daily administered by oral gavage from the 13th gestation day to the end of gestation. After birth, the offspring also received the same treatment as their mothers from day one to day twelve. After 24 hours, the newborns were sacrificed, the jaws were dissected, and the first molar teeth were collected. The samples were fixed in 10% formaldehyde solution and were histomorphologically and histopathologically observed to determine enamel and dentin abnormalities.
resultsThe mean ameloblastic layer thickness, enamel thickness, odontoblastic layer thickness, and dentin thickness were significantly different in the tetracycline group and the amoxicillin 50 and 100 mg/kg groups compared to the control group. Also, dentin hypomineralization and vacuolization of the odontoblastic layer were observed in the tetracycline- and amoxicillin-treated groups.
conclusionThis study showed that amoxicillin interferes with amelogenesis and dentinogenesis and reduces enamel and dentin thickness.
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