Evidence map›Paper›PMID 31777756›Full record

ArticleOpen forum infectious diseases2019

Trillions and Trillions: Herpes Simplex Virus-1 Hepatitis in an Immunocompetent Adult.

Kevin Ikuta, Pavitra Roychoudhury, Hong Xie, Christopher L Mcclurkan, Magdalena Walkiewicz, Negar Makhsous, Meei-Li Huang, Yodit Beru, Mariam Alam, Amanda Shepherd and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Kevin IkutaDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Pavitra RoychoudhuryDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Hong XieDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Christopher L McclurkanDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Magdalena WalkiewiczImmunopathogenesis Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA.
Negar MakhsousDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Meei-Li HuangDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Yodit BeruDivision of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Mariam AlamDivision of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Amanda ShepherdDivision of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Eric D LamotteDivision of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Kevin PatelDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Amy MorrisDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Başak ҪoruhDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
Lei YuDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Renuka BhattacharyaDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Rex ChengDivision of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Roland B WalterClinical Research Division, Fred Hutchinson Cancer Research Center Seattle, Washington, USA.
Ajit P LimayeDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Christina M LockwoodDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Steven M HollandImmunopathogenesis Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA.
Robert M RakitaDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
David M KoelleDivision of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Alexander L GreningerDepartment of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
University of Washington · USFred Hutch Cancer Center · USNational Institute of Allergy and Infectious Diseases · USBenaroya Research Institute

Funding

HOST DEFENSE TRAINING IN ALLERGY AND INFECTIOUS DISEASEST32AI007044 · NIAID · UNIVERSITY OF WASHINGTON · PI DAVID Neal FREDRICKS · 1985 to 2026
$14.6M
NIAID NIH HHS T32 AI007044
6 · The paper itself

Abstract

We describe a case of acute liver failure and myopericarditis due to herpes simplex virus-1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.

Indexed as

hepatitisherpes simplex virushost responseHSV-1HSV hepatitisviral evolution

Identifiers

PMID31777756
PMCPMC6868424
OpenAlexW2983395096

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.