ArticleAnais brasileiros de dermatologia
Serum procalcitonin and C-reactive protein in the evaluation of bacterial infection in generalized pustular psoriasis.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- IL-36-Driven Inflammation in Generalized Pustular Psoriasis: Immunological Insights from Plaque Psoriasis and Implications for Targeted Therapy.International journal of molecular sciences · 2026Review
- Tinea Incognito Imitating Pustular Psoriasis in a Psoriatic Patient Following Immunosuppressive Therapy: Case Report and Narrative Review.Journal of clinical medicine · 2026Review
- Considerations for Treating Generalized Pustular Psoriasis (GPP): A Narrative Review.Dermatology and therapy · 2025Review
- Unveiling the skin microbial guardians and assailants in psoriasis subtypes: a Mendelian randomization study.Archives of dermatological research · 2024Article
- The landscape of antibiotic usage among COVID-19 patients in the early phase of pandemic: a Malaysian national perspective.Journal of pharmaceutical policy and practice · 2022Article
- Composite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery.Journal of inflammation research · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an obvious need for more prompt and specific biomarkers of bacterial infections in generalized pustular psoriasis patients.
objectiveThe aim of this study was to evaluate the diagnostic properties and define appropriate cut-off values of procalcitonin and C-reactive protein in predicting bacterial infection in generalized pustular psoriasis patients.
methodsSixty-four generalized pustular psoriasis patients hospitalized from June 2014 to May 2017 were included in this retrospective study. The values of procalcitonin, C-reactive protein, details of infection, and other clinical parameters were analyzed.
resultsReceiver operating characteristic curve analysis generated similar areas (p=0.051) under the curve for procalcitonin 0.896 (95% CI 0.782-1.000) and C-reactive protein 0.748 (95% CI 0.613-0.883). A cut-off value of 1.50ng/mL for procalcitonin and 46.75mg/dL for C-reactive protein gave the best combination of sensitivity (75.0% for procalcitonin, 91.7% for C-reactive protein) and specificity (100% for procalcitonin, 53.8% for C-reactive protein). Procalcitonin was significantly positively correlated with C-reactive protein levels both in the infected (r=0.843, p=0.040) and non-infected group (r=0.799, p=0.000). STUDY LIMITATIONS: The sample size and the retrospective design are limitations.
conclusionsThe serum levels of procalcitonin and C-reactive protein performed equally well to differentiate bacterial infection from non-infection in generalized pustular psoriasis patients. The reference value of procalcitonin and C-reactive protein applied to predicting bacterial infection in most clinical cases may not be suitable for generalized pustular psoriasis patients. C-reactive protein had better diagnostic sensitivity than procalcitonin; however, the specificity of procalcitonin was superior to that of C-reactive protein.
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