ReviewImmunology2020
Understanding immune-microbiota interactions in the intestine.
Review in Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06560879 (Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity and Changes in Gut Microbiota in Children With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of Probiotics for the Prevention of Gastrointestinal Toxicity and Changes in Gut Microbiota in Children With Acute Lymphoblastic Leukemia
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Does micronutrient supplementation improve outcomes in adult gastrointestinal surgery patients? A systematic review.Frontiers in nutrition · 2025Pooled it
- A Rapid Advice Guideline for the Prevention of Novel Coronavirus Through Nutritional Intervention.Current nutrition reports · 2020Guideline
- Molecular Mechanisms of Gut Microbiota-Immune System Crosstalk: From Mucosal Architecture to Adaptive Immunity Programming.International journal of molecular sciences · 2026Review
- Observational
- Strain-level antigen variation facilitates immune evasion in Bacteroides thetaiotaomicron.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis.Microbiome · 2026Article
- Host Genetic Constraints on the Horizontal Transmission of Daphnia-associated Microbiota.Microbes and environments · 2026Article
- Effects of sodium butyrate on the morphology, antioxidant capacity, mitochondrial integrity, and the transcriptome of the jejunum in early weaned lambs.Frontiers in veterinary science · 2026Article
- Understanding the intricate interactions between microbiota and host.World journal of experimental medicine · 2025Review
- Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease.Biomedicines · 2025Review
- Updating the Discontinuity Theory to the Extended Immunity: The Symmunobiome Concept.European journal of immunology · 2025Review
- Mutual Interactions Between Microbiota and the Human Immune System During the First 1000 Days of Life.Biology · 2025Review
- Review
- Mucosal vaccination in a murine gnotobiotic model ofInfection and immunity · 2024Article
- The impacts of animal agriculture on One Health-Bacterial zoonosis, antimicrobial resistance, and beyond.One health (Amsterdam, Netherlands) · 2024Review
- The source of microbial transmission influences niche colonization and microbiome development.Proceedings. Biological sciences · 2024Article
- Gut microbiota mediated T cells regulation and autoimmune diseases.Frontiers in microbiology · 2024Review
- Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy.Frontiers in immunology · 2024Review
- Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell.Gut microbes · 2023Article
- Polysaccharides from Pseudostellaria heterophylla modulate gut microbiota and alleviate syndrome of spleen deficiency in rats.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The past two decades have seen an explosion in research that aims to understand how the dynamic interplay with the gut microbiota impacts host health and disease, establishing a role for the gut microbiota in a plethora of pathologies. Understanding how health-promoting microbiota are established and how beneficial host-microbiota interactions are maintained is of immense biomedical importance. Despite the enormous progress that has been made, our knowledge of the specific microbiota members that mediate these effects and the mechanisms underlying these interactions is rudimentary. The dearth of information regarding the nature of advantageous host-microbiota interactions, and the factors that cause these relationships to go awry, has hampered our ability to realize the therapeutic potential of the microbiota. Here we discuss key issues that limit current knowledge and describe a path forwards to improving our understanding of the contributions of the microbiota to host health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.