Evidence map›Paper›PMID 31776960›Full record

ArticleChinese journal of integrative medicine2020

Tiaobu Xinshen Recipe () Improved Mild Cognitive Impairment of Alzheimer's Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency.

Zhi-Ying Lin, Tian-Wen Huang, Jun-Shang Huang, Guan-Yi Zheng

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In one paragraph

Article in Chinese journal of integrative medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zhi-Ying LinDepartment of Traditional Chinese Medicine, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, 350001, China. lzy8426@126.com.
Tian-Wen HuangDepartment of Neurology, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, 350001, China.
Jun-Shang HuangKey Laboratory of Traditional Chinese Medicine for the Treatment of Brain Dysfunction, Fujian Academy of Traditional Chinese Medicine, Fuzhou, 350001, China.
Guan-Yi ZhengDepartment of Traditional Chinese Medicine, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, 350001, China.
Fujian Medical University · CNFujian University of Traditional Chinese Medicine · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo observe the intervention effects of Tiaobu Xinshen Recipe (, TXR) on patients with mild cognitive impairment caused by Alzheimer's disease (MCI-AD).

methodsTotally 88 MCI-AD patients with syndrome of Xin (Heart) and Shen (Kidney) deficiency were assigned to the experimental group (47 cases, treated with TXR) and the control group (41 cases, treated with donepezil hydrochloride) using a random number table. Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group. The therapeutic course was 12 weeks. Neuropsychological scales [mini mental state examination (MMSE) and Montreal cognitive assessment (MoCA)], and Chinese medicine (CM) dementia syndromes scales were performed in all patients, and results were compared between groups or intra-group before and after treatment.

resultsMMSE and MoCA scores of the two groups were increased after treatment compared with those before treatment (P<0.05). But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups (P>0.05). CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group (P<0.01). Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment (P<0.01).

conclusionTXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.

Indexed as

AgedAlzheimer DiseaseCognitive DysfunctionDrugs, Chinese HerbalFemaleHeart DiseasesHumansKidney DiseasesMaleMiddle AgedSurveys and QuestionnairesDrugs, Chinese HerbalAlzheimer’s diseaseChinese medicinemild cognitive impairmentmini mental state examinationMontreal cognitive assessmentTiaobu Xinshen Recipe

Identifiers

PMID31776960
OpenAlexW2989775507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.