Evidence map›Paper›PMID 31776889›Full record

ArticleInflammation2020

Investigation of Modulatory Effect of Pinolenic Acid (PNA) on Inflammatory Responses in Human THP-1 Macrophage-Like Cell and Mouse Models.

Szu-Jung Chen, Wen-Cheng Huang, Hung-Jing Shen, Ruei-Yu Chen, Hsiang Chang, Yun-Shan Ho, Po-Jung Tsai, Lu-Te Chuang

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive Review.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Szu-Jung ChenDepartment of Radiation Oncology, Tao Yuan General Hospital, TaoYuan, Taiwan.
Wen-Cheng HuangDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan.
Hung-Jing ShenDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan.
Ruei-Yu ChenDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, Hsinchu, 300, Taiwan.
Hsiang ChangDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, Hsinchu, 300, Taiwan.
Yun-Shan HoDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan.
Po-Jung TsaiDepartment of Human Development and Family Studies, National Taiwan Normal University, Taipei, Taiwan. pjtsai@ntnu.edu.tw.
Lu-Te ChuangDepartment of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, 306 Yuanpei Street, Hsinchu, 300, Taiwan. ltchuang@mail.ypu.edu.tw.ORCID http://orcid.org/0000-0002-0318-0030
National Taiwan Normal University · TWYuanpei University · TWTao Yuan General Hospital · TW

Funding

Ministry of Health and Welfare PTH10408Ministry of Science and Technology, Taiwan MOST 104-2320-B-264-002-Ministry of Science and Technology, Taiwan MOST 105-2320-B-264-001
6 · The paper itself

Abstract

Pinolenic acid (PNA) is a rare n-6 polyunsaturated fatty acid (n-6 PUFA) originally identified in pine seeds. Previous studies demonstrated that PNA and its elongation metabolite, Δ7-eicosatrienoic acid (Δ7-ETrA), exerted an anti-inflammatory effect in cultured cells by suppressing prostaglandin E

Indexed as

AnimalsAnti-Inflammatory AgentsCell LineCell SurvivalDose-Response Relationship, DrugHumansInflammation MediatorsLinolenic AcidsMacrophagesMaleMiceMice, Inbred ICRSkinTHP-1 Cells5,9,12-octadecatrienoic acidAnti-Inflammatory AgentsInflammation MediatorsLinolenic Acidsinflammationmouse ear edemapinolenic acid (PNA)polyunsaturated fatty acids (PUFA)Δ7-eicosatrienoic acid (Δ7-ETrA)

Identifiers

PMID31776889
OpenAlexW2990825496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.