ArticleGeroScience2020
Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice.
Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction.Nature communications · 2026Article
- Immediate impacts of low-temperature exposure on cardiac autonomic modulation, neuromuscular efficiency, and postural stability in older adults Yangko dancers - a randomized controlled trial.Frontiers in physiology · 2026Article
- Thermoneutral environment improves mouse welfare and reduces stress in metabolic cages.Lab animal · 2025Article
- Lean Mice Exposed to Early Life Stress Exhibit Increased Basal Sympathetic Tone and Blunted Parasympathetic Activation in Response to High Salt Diet.Comprehensive physiology · 2025Article
- Cold Exposure Exacerbates Cardiac Dysfunction in a Model of Heart Failure with Preserved Ejection Fraction in Male and Female C57Bl/6J Mice.Biomedicines · 2025Article
- The Impacts of Housing Conditions on the Cardiopulmonary and Neurobehavioral Responses of Mice to High Temperature and Wildfire Smoke.Environmental science & technology · 2025Article
- Cardiovascular function and autonomic regulation in urethane-anesthetized and conscious mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity.PLoS computational biology · 2024Article
- How is Big Data reshaping preclinical aging research?Lab animal · 2023Review
- What to consider for ECG in mice-with special emphasis on telemetry.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- High pulse pressure impairs cerebral artery endothelial function in young, but not old, mice.Experimental gerontology · 2023Article
- How murine models of human disease and immunity are influenced by housing temperature and mild thermal stress.Temperature (Austin, Tex.) · 2023Review
- Sex differences in heart rate and heart rate variability in rats: Implications for translational research.Frontiers in physiology · 2023Article
- Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks.Frontiers in physiology · 2022Article
- Evaluation of non-linear heart rate variability using multi-scale multi-fractal detrended fluctuation analysis in mice: Roles of the autonomic nervous system and sinoatrial node.Frontiers in physiology · 2022Article
- Sustained hypoxia in mice increases parasympathetic but not sympathetic tone.Current research in physiology · 2022Article
- Roles of cardiovascular autonomic regulation and sleep patterns in high blood pressure induced by mild cold exposure in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice.Frontiers in neuroscience · 2021Article
- Opening the Schrödinger Box: Short- and Long-Range Mammalian Heart Rate Variability.Frontiers in physiology · 2021Article
- Beating Rate Variability of Isolated Mammal Sinoatrial Node Tissue: Insight Into Its Contribution to Heart Rate Variability.Frontiers in neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice are among the most widely used translational models of cardiovascular aging and offer a method to quickly assess lifespan changes in a controlled environment. The standard laboratory temperature (20-22 °C), however, imposes a cold stress on mice that causes an increase in sympathetic nervous system-mediated activation of brown adipose tissue (BAT) to maintain a core body temperature of 36-37 °C. Thus, while physiologic data obtained recapitulate human physiology to a certain degree, interpretations of previous research in mice may have been contaminated by a cold stress, due to housing mice below their thermoneutral zone (30 °C). The purpose of this investigation was to examine how chronic sympathetic stimulation evoked by acclimation to 20 °C might obscure interpretation of changes in autonomic modulation of heart rate (HR) and heart rate variability (HRV) that accompany advancing age. HR and HRV before and after administration of a dual-autonomic blockade were measured via in-vivo ECG in young (3 months) and aged (30 months) male C57BL/6 telemetry-implanted mice following temperature acclimation for 3 days at 30 °C or 20 °C. Mean basal and intrinsic HR of both young and aged mice became markedly reduced at 30 °C compared to 20 °C. In both age groups, HRV parameters in time, frequency, and non-linear domains displayed increased variability at 30 °C compared to 20 °C under basal conditions. Importantly, age-associated declines in HRV observed at 20 °C were ameliorated when mice were studied at their thermoneutral ambient temperature of 30 °C. Thus, an accurate understanding of autonomic modulation of cardiovascular functions in mice of advanced age requires that they are housed in a metabolically neutral environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.