Evidence map›Paper›PMID 31776834›Full record

ArticleIrish journal of medical science2020

Mitochondrial tRNA

Ping Yang, Peng Wu, Xing Liu, Jian Feng, Shuzhan Zheng, Yan Wang, Zhongcai Fan

Abstract read
PubMed Publisher
In one paragraph

Article in Irish journal of medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Mitochondrial tRNA-Derived Diseases.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Novel mitochondrial tRNAIrish journal of medical science · 2023
    Article
  4. The Mitochondrial tRNALife (Basel, Switzerland) · 2023
    Review
  5. The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ping YangDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China.
Peng WuCardiovascular Medicine Department, Ya'an People's Hospital, Ya'an City, Sichuan, 646000, People's Republic of China.
Xing LiuDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China.
Jian FengDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China.
Shuzhan ZhengDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China.
Yan WangDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China.
Zhongcai FanDepartment of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, NO 25 Taiping Street, Luzhou City, 646000, Sichuan Province, China. fanzc001@aliyun.com.
Affiliated Hospital of Southwest Medical University · CN

Funding

Key Laboratory of Medical Electrophysiology of Ministry of Education KeyME-2017-07
6 · The paper itself

Abstract

objectiveThe objective of the study was to investigate the association between mitochondrial DNA (mtDNA) mutations and essential hypertension (EH).

methodsOne Han Chinese pedigree with maternally inherited EH was recruited in the current study. The matrilineal relatives from this family underwent clinical, genetic, and molecular analysis. Moreover, the mtDNA gene mutations were screened by PCR and direct Sanger sequence. Evolutionary conservation was performed and the secondary structure of mt-tRNA

resultsThis Chinese pedigree exhibited a relative high penetrance and expressivity of EH. Of 13 matrilineal relatives, 5 of them suffered from high blood pressure (BP). Genetic analysis of the complete mtDNA genes showed the presence of a novel tRNA

conclusionWe believed that the 7471delC may impair the mitochondrial functional and played an active role in the pathogenesis of EH in this pedigree. The 7471delC may be a novel risk factor for maternally transmitted EH.

Indexed as

DNA, MitochondrialFemaleHumansHypertensionMaleMutationPolymorphism, GeneticRNA, Transfer, SerDNA, MitochondrialRNA, Transfer, SerEHMitochondrial dysfunctionMt-tRNASer(UCN) 7471delCNovel

Identifiers

PMID31776834
OpenAlexW2990006424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.