ArticleEuropean journal of epidemiology2020
Association of aortic stiffness with cognitive decline: Whitehall II longitudinal cohort study.
Article in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Arterial stiffness measured by pulse wave velocity correlated with cognitive decline in hypertensive individuals: a systematic review.BMC neurology · 2024Pooled it
- Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- One-year aerobic exercise increases cerebral blood flow in cognitively normal older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Trial
- Changes in adiposity indices over 10 years and risk of type 2 diabetes: The Whitehall II cohort study.Diabetes, obesity & metabolism · 2025Article
- Beneficial Effects of Water-Based Exercise Alone and in Combination with Cognitive Training on Cardiovascular Fitness and Arterial Stiffness in Older Adults with Mild Cognitive Impairment: A Randomized Controlled Trial.Life (Basel, Switzerland) · 2025Article
- Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study.BMC medicine · 2025Article
- Brachial-Ankle Pulse Wave Velocity is Associated with Incident Dementia in Patients with Cerebral Small-Vessel Disease.Journal of atherosclerosis and thrombosis · 2025Article
- Estimated Pulse Wave Velocity Is Associated With a Higher Risk of Dementia in the Health and Retirement Study.American journal of hypertension · 2024Article
- Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment.Scientific reports · 2024Article
- Arterial stiffness and its influence on cerebral morphology and cognitive function.Therapeutic advances in neurological disorders · 2023Article
- Potential Protective Mechanisms of S-equol, a Metabolite of Soy Isoflavone by the Gut Microbiome, on Cognitive Decline and Dementia.International journal of molecular sciences · 2022Review
- Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences.Physiology (Bethesda, Md.) · 2022Review
- The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.Frontiers in cardiovascular medicine · 2022Article
- Pulsatile tympanic membrane displacement is associated with cognitive score in healthy subjects.Cerebral circulation - cognition and behavior · 2022Article
- Associations between arterial stiffening and brain structure, perfusion, and cognition in the Whitehall II Imaging Sub-study: A retrospective cohort study.PLoS medicine · 2020Observational
- Objectives, design and main findings until 2020 from the Rotterdam Study.European journal of epidemiology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Aortic stiffness is associated with an increased risk of cardio- and cerebrovascular disease and mortality and may increase risk of dementia. The aim of the present study is to examine the association between arterial stiffness and cognitive decline in a large prospective cohort study with three repeated cognitive assessment over 7 years of follow-up. Aortic pulse wave velocity (PWV) was measured among 4300 participants (mean ± standard deviation age 65.1 ± 5.2 years) in 2007-2009 and categorized based on the tertiles: (lowest third: < 7.41 m/s), (middle third: 7.41-8.91 m/s), and (highest third: > 8.91 m/s). A global cognitive score was calculated in 2007-2009, 2012-2013, and 2015-2016 based on responses to memory, reasoning and fluency tests. Standardized global cognitive score (mean = 0, SD = 1) in highest third versus lowest third of PWV category was lower at baseline (- 0.12, 95% CI - 0.18, - 0.06). Accelerated 7-year cognitive decline was observed among individuals with the highest PWV [difference in 7-year cognitive change for highest third versus lowest third PWV: - 0.06, 95% CI - 0.11, - 0.01, P < 0.01]. Higher aortic stiffness was associated with faster cognitive decline. Clinicians may be able to use arterial stiffness severity as an indicator to administer prompt treatments to prevent or delay the onset of cognitive decline or dementia. Future studies need to determine whether early intervention of vascular stiffness is effective in delaying these outcomes.
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Registered trials
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