ArticleInternational journal of implant dentistry2019
Dental implants in immunocompromised patients: a systematic review and meta-analysis.
Article in International journal of implant dentistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Comprehensive Update on Implants in Patients With Head and Neck Cancer (2021-2024): Systematic Review and Meta-Analysis of the Impact of Radiotherapy and Chemotherapy on Implant Survival.Clinical oral implants research · 2025Pooled it
- Oral health and rehabilitation in face transplant recipients - a systematic review.Clinical oral investigations · 2025Pooled it
- A Systematic Analysis of the Available Human Clinical Studies of Dental Implant Failure in Patients with Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Effect of Medication Intake on Dental Implant-Related Outcomes-A Scoping Review.Clinical oral implants research · 2026Article
- Multivariate Analysis of the Survival Rates and Risk Factors of One-Piece Zirconia Implants Supporting Single Crowns or Fixed Dental Prostheses: A Retrospective Cohort Study with Follow-Up Periods of up to 8 Years.Dentistry journal · 2026Article
- Indications and Regenerative Techniques for Lateral Window Sinus Floor Elevation With Ridge Augmentation.Clinical implant dentistry and related research · 2025Review
- Using the Immune System for Effective Periodontal and Caries Management.BioMed research international · 2025Review
- Prosthetic rehabilitation of patients with maxillary oncology defects using zygomatic implants.International journal of implant dentistry · 2024Article
- Bone Metabolism and Dental Implant Insertion as a Correlation Affecting on Marginal Bone Remodeling: Texture Analysis and the New Corticalization Index, Predictor of Marginal Bone Loss-3 Months of Follow-Up.Journal of clinical medicine · 2024Article
- Review
- Quality of life in patients in South Korea requiring special care after fixed implants: a retrospective analysis.BMC oral health · 2023Article
- Immunomodulators and Their Applications in Dentistry and Periodontics: A Comprehensive Review.Cureus · 2023Review
- Short versus Standard Length Implants with Sinus Floor Elevation for the Atrophic Posterior Maxilla.Acta stomatologica Croatica · 2022Article
- Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity.Biomedical materials (Bristol, England) · 2022Review
- Prevalence of peri-implantitis in a sample of HIV-positive patients.Clinical and experimental dental research · 2021Article
- Success Rate of Dental Implants in Patients with Autoimmune Disorders: A Systematic Review and Meta-Analysis.Journal of International Society of Preventive & Community DentistryReview
- Dental and ENT Evaluation Before Liver Transplantation.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveImpaired health conditions and related lack of adequate host healing are among the most important conditions that account for dental implant failure. Today clinicians face an increasing number of immunocompromised patients requesting implant-based rehabilitation. To provide clinical evidence for prospective decision-making, the aim of this systematic review and meta-analysis was to analyse the influence of immunodeficiency on dental implant survival.
methodsThe study was conducted according to the PRISMA Statement and the principles of the Cochrane Collaboration. MEDLINE and Web of Science were searched. Results were calculated by the pooled incidence of implant loss. Reported odds ratios (OR) from fully adjusted models were preferred. Distinct risk estimates were synthesised with 95% confidence intervals.
resultsA total of 62 publications including 1751 endosseous implants placed in immunocompromised patients were included. For the follow-up of 24 months and longer, the mean survival rate of implants in patients with HIV was 93.1%, chemotherapy was 98.8%, autoimmune disease was 88.75%, after organ transplantation was 100%. Crohn's disease showed a significant effect on early implant failure and resulted in increased, however not significant, implant loss.
conclusionNo significant effect of immunocompromised conditions on implant survival was detectable. Implant-based therapy in immunocompromised patients should not aggravate the general morbidity and must not interfere in life-saving therapies. A careful risk stratification prior implant therapy is fundamental. To further decipher the role of immunosuppression on dental implantology, more data from controlled and randomised studies are needed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.