Evidence map›Paper›PMID 31776773›Full record

ReviewCurrent hematologic malignancy reports2019

Health-Related Quality of Life and Treatment of Older Adults with Acute Myeloid Leukemia: a Young International Society of Geriatric Oncology Review Paper.

Kah Poh Loh, Maya Abdallah, Anita J Kumar, Nina R Neuendorff, Saurabh Dahiya, Heidi D Klepin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current hematologic malignancy reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kah Poh LohJames P. Wilmot Cancer Institute, Division of Hematology/Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY, 14642, USA. kahpoh_loh@urmc.rochester.edu.
Maya AbdallahDepartment of Internal Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
Anita J KumarDivision of Hematology/Oncology, Tufts Medical Center, Boston, MA, USA.
Nina R NeuendorffDepartment of Internal Medicine V, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Saurabh DahiyaMarlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Heidi D KlepinSection on Hematology and Oncology, Wake Forest Baptist Comprehensive Cancer Center, Medical Center Blvd, Winston-Salem, NC, USA.

Funding

A novel mobile health exercise intervention for older patients with myeloid neoplasmsR00CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2021 to 2023
$747k
A Novel Mobile Health Exercise Intervention for Older Patients with Myeloid NeoplasmsK99CA237744 · NCI · UNIVERSITY OF ROCHESTER · PI LOH, KAH POH · 2019 to 2020
$385k
NCI NIH HHS K99 CA237744NCI NIH HHS R00 CA237744
6 · The paper itself

Abstract

purpose of reviewThe treatment landscape for older patients with acute myeloid leukemia (AML) is evolving. Many treatments have comparable efficacy making their impact on quality of life (QoL) an important differentiating factor. In this review, we discuss QoL in older adults with AML, focusing on therapeutic and observational trials that have incorporated QoL assessments. RECENT

findingsHealth-related quality of life (HRQoL) is a multi-dimensional concept incorporating physical, mental, emotional, and social functioning domains. HRQoL components overlap with components of geriatric assessment, a multidisciplinary diagnostic process that identifies underlying vulnerabilities of older adults and guides subsequent management strategies. HRQoL questionnaires may be general, cancer-specific, leukemia-specific, or symptom-focused. Therapeutic and observational cohort studies suggest HRQoL improves, or at least remains stable, during intensive and lower-intensity therapies. Nonetheless, HRQoL is not routinely incorporated in AML therapeutic trials. HRQoL assessments can inform both decision-making and management for older adults with AML.

Indexed as

Geriatric AssessmentQuality of LifeAgedAged, 80 and overAge FactorsClinical Decision-MakingClinical Trials as TopicCombined Modality TherapyDisease ManagementHealth Care SurveysHumansLeukemia, Myeloid, AcuteSurveys and QuestionnairesTreatment OutcomeAcute myeloid leukemiaGeriatric assessmentIntensive therapiesLower intensity therapiesQuality of lifeTherapeutic trials

Identifiers

PMID31776773
PMCPMC6938300

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.