ArticleEuropean radiology2020
Computed tomography-guided lung biopsy: a randomized controlled trial of low-dose versus standard-dose protocol.
Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Low-dose Protocol for Computed Tomography-guided Lung Biopsy
Low-dose Computed Tomography-guided Core Needle Biopsy for Lung Nodules
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The value of chest CT in the differential diagnosis of benign and malignant pulmonary nodules: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Usefulness of computed tomography-guided puncture biopsy coupled with rapid on‑site evaluation for diagnosis of pulmonary lesions: a systematic review and meta‑analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Pooled it
- A systematic review and meta-analysis of randomized controlled trials comparing low-dose versus standard-dose computed tomography-guided lung biopsy.Journal of cardiothoracic surgery · 2024Pooled it
- Computed tomography-guided lung biopsy with rapid on-site evaluation for diagnosis of lung lesions: a meta-analysis.Journal of cardiothoracic surgery · 2023Pooled it
- Spectral shaping technology reduces the radiation dose of CT-guided lung tumor microwave ablation.Scientific reports · 2025Trial
- Low-dose versus standard-dose computed tomography-guided biopsy for pulmonary nodules: a randomized controlled trial.Journal of cardiothoracic surgery · 2023Trial
- Procedural efficiency, diagnostic yield, and safety of a novel positioning grid combined with a non-coplanar puncture-angle guide for CT-guided percutaneous transthoracic lung biopsy: a retrospective contemporaneous-control study.Journal of thoracic disease · 2026Article
- Cutting doses, keeping diagnoses: outcomes of protocol optimization for CT-guided lung biopsies.La Radiologia medica · 2026Article
- Article
- The Usefulness of Extemporaneous Cytological Examination in Imaging-Guided Biopsies.Animals : an open access journal from MDPI · 2025Article
- Comparison of low- and standard-dose CT-guided transthoracic core needle biopsies: Feasibility, safety, diagnostic yield, and radiation dose.Acta radiologica open · 2025Article
- Accurate puncture of targets in the lower lung lobes with respiratory motion using a teleoperated robotic system and low-dose computed tomography fluoroscopy: an experimental animal study.Quantitative imaging in medicine and surgery · 2025Article
- Comparison of computed tomography-guided core needle biopsy of pulmonary nodules performed with and without the coaxial technique.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Article
- Ultrasound versus computed tomography guided percutaneous needle biopsy for subpleural pulmonary lesions.Frontiers in oncology · 2024Article
- Systematic review and meta-analysis of low-dose CT-driven biopsy for pulmonary nodules.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023Article
- Patient Dose Estimation in Computed Tomography-Guided Biopsy Procedures.Journal of imaging · 2023Article
- Comparison between percutaneous transthoracic co-axial needle CT-guided biopsy and transbronchial lung biopsy for the diagnosis of persistent pulmonary consolidation.Insights into imaging · 2023Article
- Computed tomography-guided lung biopsy for molecular tests: a meta-analysis.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2022Article
- Three-dimensionally printed navigational template: a promising guiding approach for lung biopsy.Translational lung cancer research · 2022Article
- Low-dose CT with tin filter combined with iterative metal artefact reduction for guiding lung biopsy.Quantitative imaging in medicine and surgery · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the relative diagnostic utility of low- and standard-dose computed tomography (CT)-guided lung biopsy.
methodsIn this single-center, single-blind, prospective, randomized controlled trial, patients were enrolled between November 2016 and June 2017. Enrolled study participants were randomly selected to undergo either low- or standard-dose CT-guided lung biopsy. Diagnostic accuracy was the primary study endpoint, whereas technical success, radiation dose, and associated complications were secondary study endpoints.
resultsIn total, 280 patients underwent study enrollment and randomization, with 271 (low-dose group, 135; standard-dose group, 136) receiving the assigned interventions. Both groups had a 100% technical success rate for CT-guided lung biopsy, and complication rates were similar between groups (p > 0.05). The mean dose-length product (36.0 ± 14.1 mGy cm vs. 361.8 ± 108.0 mGy cm, p < 0.001) and effective dose (0.5 ± 0.2 mSv vs. 5.1 ± 1.5 mSv, p < 0.001) were significantly reduced in the low-dose group participants. Sensitivity, specificity, and overall diagnostic accuracy rates in the low-dose group were 91.8%, 100%, and 94.6%, respectively, whereas in the standard-dose group, the corresponding values were 89.6%, 100%, and 92.4%, respectively. These results indicated that diagnostic performance did not differ significantly between the 2 groups. Using univariate and multivariate analyses, we found larger lesion size (p = 0.038) and procedure-related pneumothorax (p = 0.033) to both be independent predictors of diagnostic failure.
conclusionsOur results demonstrate that low-dose CT-guided lung biopsy can yield comparable diagnostic accuracy to standard-dose CT guidance, while significantly reducing the radiation dose delivered to patients.
trial registrationClinicalTrials.gov NCT02971176 KEY POINTS: • Low-dose CT-guided lung biopsy is a safe and simple method for diagnosis of lung lesions. • Low-dose CT-guided lung biopsy can yield comparable diagnostic accuracy to standard-dose CT guidance. • Low-dose CT-guided lung biopsy can achieve a 90% reduction in radiation exposure when compared with standard-dose CT guidance.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.