Evidence map›Paper›PMID 31776723›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2019

The JAX Synteny Browser for mouse-human comparative genomics.

Georgi Kolishovski, Anna Lamoureux, Paul Hale, Joel E Richardson, Jill M Recla, Omoluyi Adesanya, Al Simons, Govindarajan Kunde-Ramamoorthy, Carol J Bult

Abstract readComparative Study
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Visualizing metagenomic and metatranscriptomic data: A comprehensive review.Computational and structural biotechnology journal · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Genetic variants inmedRxiv : the preprint server for health sciences · 2023
    Article
  12. Review
  13. Multi-View Design Patterns and Responsive Visualization for Genomics Data.IEEE transactions on visualization and computer graphics · 2023
    Review
  14. Fine mapping and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  15. Article
  16. Mouse Genome Informatics (MGI): latest news from MGD and GXD.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Article
  17. Article
  18. Review
  19. Cells · 2021
    Article
  20. The clear cell sarcoma functional genomic landscape.The Journal of clinical investigation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georgi KolishovskiThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Anna LamoureuxThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Paul HaleThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Joel E RichardsonThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Jill M ReclaThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Omoluyi AdesanyaThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Al SimonsThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA.
Govindarajan Kunde-RamamoorthyThe Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA. govind.ramamoorthy@jax.org.
Carol J BultThe Jackson Laboratory for Mammalian Genomics, Bar Harbor, ME, 04609, USA. carol.bult@jax.org.ORCID 0000-0001-9433-210X

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Mouse Genome DatabaseU41HG000330 · NHGRI · JACKSON LABORATORY · PI BLAKE, JUDITH A, BULT, CAROL J · 2011 to 2020
$45.5M
Mouse Models of Human Cancer DatabaseR01CA089713 · NCI · JACKSON LABORATORY · PI BULT, CAROL J · 2002 to 2025
$17.5M
Diversity Action Plan for Mouse Genome DatabaseR25HG007053 · NHGRI · JACKSON LABORATORY · PI BULT, CAROL J · 2013 to 2020
$558k
NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA089713NHGRI NIH HHS R25 HG007053NHGRI NIH HHS U41 HG000330
6 · The paper itself

Abstract

Visualizing regions of conserved synteny between two genomes is supported by numerous software applications. However, none of the current applications allow researchers to select genome features to display or highlight in blocks of synteny based on the annotated biological properties of the features (e.g., type, function, and/or phenotype association). To address this usability gap, we developed an interactive web-based conserved synteny browser, The Jackson Laboratory (JAX) Synteny Browser. The browser allows researchers to highlight or selectively display genome features in the reference and/or the comparison genome according to the biological attributes of the features. Although the current implementation for the browser is limited to the reference genomes for the laboratory mouse and human, the software platform is intentionally genome agnostic. The JAX Synteny Browser software can be deployed for any two genomes where genome coordinates for syntenic blocks are defined and for which biological attributes of the features in one or both genomes are available in widely used standard bioinformatics file formats. The JAX Synteny Browser is available at: http://syntenybrowser.jax.org/. The code base is available from GitHub: https://github.com/TheJacksonLaboratory/syntenybrowser and is distributed under the Creative Commons Attribution license (CC BY).

Indexed as

GenomicsInternetAnimalsDiabetes Mellitus, Type 2Gene OntologyHumansMiceQuantitative Trait LociSyntenyBioinformaticsCandidate gene analysisComparative genomicsConserved synteny

Identifiers

PMID31776723
PMCPMC6892358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.