ArticleNature2019
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
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In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
20.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- How has mass drug administration with dihydroartemisinin-piperaquine impacted molecular markers of drug resistance? A systematic review.Malaria journal · 2022Pooled it
- Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.Nature microbiology · 2026Article
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- Evaluation of Antiplasmodial Activity of Quinoline Derivatives Incorporating Arylnitro and Aminochalcone Moieties.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Structural basis for transport and inhibition of nucleotide sugar transport in pathogenic fungi.Nature communications · 2026Article
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- Optimized bacterial expression of a synthetic BRIL antibody.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Changing genetic profiles ofAntimicrobial agents and chemotherapy · 2026Article
- Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.Nature communications · 2026Article
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- Differential expression of mitochondria-associated genes in clinical samples of Plasmodium falciparum showing severe manifestations.BMC genomics · 2026Article
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- Tailored for swift recognition: A structural perspective on secondary active plant hormone transporters.The Plant journal : for cell and molecular biology · 2026Review
- Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Trimbody with rigid AI-designed scaffolds enables atomic-resolution cryo-EM structure determination of small proteins.Nature communications · 2026Article
- Strategic advances for cryo-EM structural studies of small (<100 kDa) GPCRs.Communications biology · 2026Review
- Expression and Purification of Integral Membrane Enzymes for Functional and Structural Studies.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1.Nature communications · 2025Article
- Memorization bias impacts modeling of alternative conformational states of solute carrier membrane proteins with methods from deep learning.PLoS computational biology · 2025Article
- Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites.Antimicrobial agents and chemotherapy · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Jonathan Kim *Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Yong Zi Tan *Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Kathryn J WichtDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Satchal K ErramilliDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Satish K DhingraDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
John OkomboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Jeremie VendomeSchrödinger, New York, NY, USA.
Laura M HagenahDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Sabrina I GiacomettiDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Audrey L WarrenDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Kamil NosolDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Paul D RoepeDepartment of Chemistry, Georgetown University, Washington, DC, USA.
Clinton S PotterNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Bridget CarragherNational Resource for Automated Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center, New York, NY, USA.
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Matthias QuickDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA. mq2102@cumc.columbia.edu.
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2260@cumc.columbia.edu.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA. fm123@cumc.columbia.edu.
Columbia University Irving Medical Center · USUniversity of Chicago · USNew York Structural Biology Center · USGeorgetown University · USSchrodinger (United States) · US
Funding
ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI SCOTT, EMILY E · 1985 to 2011
$38.9MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MThe Function of Antimalarial Drug Resistance ProteinsR01AI056312 · NIAID · GEORGETOWN UNIVERSITY · PI PAUL D. ROEPE · 2003 to 2026
$7.5MTraining (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1MRole of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7MLeveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant MalariaR01AI147628 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock, Filippo Mancia · 2019 to 2026
$5.1MOptimized Combination Antimalarial Drug TherapyR01AI111962 · NIAID · GEORGETOWN UNIVERSITY · PI ROEPE, PAUL D., SULLIVAN, DAVID JOSEPH · 2014 to 2018
$4.9MTraining in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7MDefining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4MDefining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4MElucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MNCRR NIH HHS P41 RR001209NHLBI NIH HHS T32 HL120826NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI050612NIAID NIH HHS R01 AI056312NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI111962NIAID NIH HHS R01 AI124678NIAID NIH HHS R01 AI147628NIAID NIH HHS R37 AI050234NIAID NIH HHS T32 AI106711NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R01 GM111980NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R01 GM119396NIGMS NIH HHS R35 GM132120
Abstract
The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts to control and eliminate malaria. For decades, treatment of malaria has relied on chloroquine (CQ), a safe and affordable 4-aminoquinoline that was highly effective against intra-erythrocytic asexual blood-stage parasites, until resistance arose in Southeast Asia and South America and spread worldwide
Indexed as
Cryoelectron MicroscopyChloroquineDrug ResistanceHydrogen-Ion ConcentrationMalaria, FalciparumMembrane Transport ProteinsModels, MolecularMutationPiperazinesPlasmodium falciparumProtozoan ProteinsQuinolinesChloroquineMembrane Transport ProteinsPfCRT protein, Plasmodium falciparumpiperaquinePiperazinesProtozoan ProteinsQuinolines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.