Evidence map›Paper›PMID 31776512›Full record

ArticleNature2019

Bile acid metabolites control T

Saiyu Hang, Donggi Paik, Lina Yao, Eunha Kim, Jamma Trinath, Jingping Lu, Soyoung Ha, Brandon N Nelson, Samantha P Kelly, Lin Wu and 8 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 897 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
897citing papers in PubMed, 1 pooled it
45.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

897 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,300 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
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  17. Review
  18. Role of Bile Acid Receptors in Non-Infectious Diarrhea: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  19. Bile acid signaling in health and disease.Molecular biomedicine · 2026
    Review
  20. Review

837 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 3 countries.

Saiyu Hang *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Donggi Paik *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Lina YaoDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Eunha KimDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Jamma TrinathDepartment of Biological Sciences, Birla Institute of Technology and Science, Hyderabad, India.
Jingping LuTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Soyoung HaDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Brandon N NelsonDepartment of Chemistry, Bucknell University, Lewisburg, PA, USA.
Samantha P KellyDepartment of Chemistry, Bucknell University, Lewisburg, PA, USA.
Lin WuThe Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA.
Ye ZhengImmunobiology and Microbial Pathogenesis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Randy S LongmanJill Roberts Center for IBD, Weill Cornell Medicine, New York, NY, USA.
Fraydoon RastinejadTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
A Sloan DevlinDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Michael R KroutDepartment of Chemistry, Bucknell University, Lewisburg, PA, USA.
Michael A FischbachDepartment of Bioengineering, Stanford University, Stanford, CA, USA. fischbach@fischbachgroup.org.
Dan R LittmanThe Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY, USA. Dan.Littman@med.nyu.edu.
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. jun_huh@hms.harvard.edu.
Harvard University · USBucknell University · USBoston VA Research Institute · USUniversity of Oxford · GBBirla Institute of Technology and Science - Hyderabad Campus · INCornell University · USHoward Hughes Medical Institute · USNew York University · USSalk Institute for Biological Studies · USStanford University · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Bacterial metabolites controlling Th17 cellsR01DK110559 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUH, JUN R. · 2016 to 2024
$5.1M
Treg development and function controlled by cis-regulatory circuitsR01AI107027 · NIAID · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2014 to 2022
$5.0M
Roles of nucleoporins in RORgammat-dependent immune functionsR01AI080885 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LITTMAN, DAN · 2009 to 2020
$4.3M
A network model of the gut host-microbe ecosystem in Inflammatory Bowel DiseaseR01DK103358 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BONNEAU, RICHARD A, LITTMAN, DAN · 2014 to 2018
$3.2M
Host-Microbiota Interactions in Crohn's Disease-associated SpondyloarthritisR01DK114252 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI LONGMAN, RANDY S · 2018 to 2022
$1.9M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI080885NIAID NIH HHS R01 AI107027NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK103358NIDDK NIH HHS R01 DK110559NIDDK NIH HHS R01 DK114252Wellcome Trust 210664/Z/18/Z
6 · The paper itself

Abstract

Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is unknown whether they affect adaptive immune cells such as T helper cells that express IL-17a (T

Indexed as

AnimalsCell DifferentiationForkhead Transcription FactorsLithocholic AcidMiceMice, Inbred C57BLReactive Oxygen SpeciesTh17 CellsT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouseLithocholic AcidReactive Oxygen Species

Identifiers

PMID31776512
PMCPMC6949019
OpenAlexW2990182987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.