ArticleHypertension research : official journal of the Japanese Society of Hypertension2020
Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: the Saku study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 38 citations in OpenAlex.
- Uric Acid and Chronic Kidney Disease.Kidney medicine · 2026Review
- Shear wave elastography to evaluate the effect of serum uric acid levels on carotid artery elasticity in patients with high-normal blood pressure.Journal of medical biochemistry · 2025Article
- Associations of serum uric acid trajectories with hypertension risk: exploring differences between age groups.Frontiers in cardiovascular medicine · 2025Article
- Characteristics and Risk of Diabetes in People With Rare Glucose Response Curve During an Oral Glucose Tolerance Test.The Journal of clinical endocrinology and metabolism · 2024Article
- Gender differences in all-cause and cardiovascular mortality among US adults: from NHANES 2005-2018.Frontiers in cardiovascular medicine · 2024Article
- Development and validation of a prediction model for hyperuricemia risk in hypertensive patients.American journal of cardiovascular disease · 2024Article
- The Role of Uric Acid in Human Health: Insights from theJournal of personalized medicine · 2023Review
- The reality of treatment for hyperuricemia and gout in Japan: A historical cohort study using health insurance claims data.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Serum Uric Acid and Hyperuricemia Associate with Coronary Artery Disease among Postmenopausal Women.Reviews in cardiovascular medicine · 2022Article
- Development of a risk prediction score for hypertension incidence using Japanese health checkup data.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Impact of hyperuricemia on chronic kidney disease and atherosclerotic cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Effect of chronic kidney disease on the association between hyperuricemia and new-onset hypertension in the general Japanese population: ISSA-CKD study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- J-shaped curve for the association between serum uric acid levels and the prevalence of blood pressure abnormalities.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Association of childhood anthropometric measurements and laboratory parameters with high blood pressure in young adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- The interaction on hypertension between family history and diabetes and other risk factors.Scientific reports · 2021Article
- Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update.Cardiology journal · 2021Article
- Prospective Study of Serum Uric Acid Levels and First Stroke Events in Chinese Adults With Hypertension.Frontiers in physiology · 2021Article
- Uric acid and hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Effects of Tart Cherry Powder on Serum Uric Acid in Hyperuricemia Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Update on the epidemiology, genetics, and therapeutic options of hyperuricemia.American journal of translational research · 2020Review
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10 authors at 7 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia has been reported to be a risk factor for hypertension, but this association may be affected by alcohol consumption. This study aimed to investigate whether hyperuricemia remains a risk factor for hypertension after eliminating the effect of alcohol consumption. This study comprised 7848 participants (4247 men and 3601 women) aged 30-74 years without hypertension who had undergone a medical checkup between April 2008 and March 2009 at Saku Central Hospital, Nagano Prefecture, Japan. Hyperuricemia was defined as uric acid >7.0 mg/dl in men, ≥6.0 mg/dl in women, and/or receiving treatment for hyperuricemia or gout. The incidence of hypertension was defined as the first diagnoses of blood pressure ≥140/≥ 90 mmHg and/or initiations of antihypertensive drug treatment. Multivariable-adjusted hazard ratios (HRs) of hyperuricemia for the incidence of hypertension after adjustment for and classification by alcohol consumption were estimated using the Cox proportional hazard model. During a mean of 4.0 years of follow-up, 1679 individuals developed hypertension. After adjustment for alcohol consumption, the HRs (95% confidence interval) associated with hyperuricemia were 1.37 (1.19-1.58) in men and 1.54 (1.14-2.06) in women. Among nondrinkers, the HR was 1.29 (0.94-1.78) in men with hyperuricemia compared with men without, and the corresponding HR was 1.57 (1.11-2.22) in women. The corresponding HR was 1.88 (1.27-2.86) in all participants with baseline blood pressure <120/80 mmHg. The interactions between hyperuricemia and sex (P = 0.534) and between drinking and sex (P = 0.713) were not significant. In conclusion, hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status.
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