ArticleEuropean journal of clinical nutrition2020
Association between serum folate and cardiovascular deaths among adults with hypertension.
Article in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.Journal of advanced research · 2026Review
- Evaluating the Impact of Folate on Male Infertility Using Mendelian Randomization: A Comprehensive Analysis.The world journal of men's health · 2026Article
- Interactive effects of folate and methylmalonic acid on cardiovascular disease mortality: Epidemiological and experimental evidence.iScience · 2025Article
- Association between RBC folate and odds of osteoarthritis in adults aged 40-60 years.Scientific reports · 2025Article
- Association of dietary intake of folate, serum folate, and red blood cell folate with mortality risk in patients with depression: a population-based longitudinal cohort study.Journal of health, population, and nutrition · 2025Article
- Association of serum folate concentrations with cancer mortality among patients with arthritis: a prospective cohort study.BMC public health · 2024Article
- Nomogram for Predicting the Risk of Short Sleep Duration in Myocardial Infarction Survivors.Reviews in cardiovascular medicine · 2024Article
- Association between Serum Folate and Vaginal High-Risk Human Papillomavirus Infections in United States Women.The Journal of nutrition · 2024Article
- Association Between High Blood Folate Levels and Glaucoma in a Representative Korean Population.Investigative ophthalmology & visual science · 2024Article
- Article
- The Role of One-Carbon Metabolism in Healthy Brain Aging.Nutrients · 2023Review
- Folate and cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Non-linear associations of serum and red blood cell folate with risk of cardiovascular and all-cause mortality in hypertensive adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Comparison of insulin resistance-associated parameters in US adults: a cross-sectional study.Hormones (Athens, Greece) · 2023Article
- Effect of baseline resting heart rate on the risk of all-cause death in Chinese patients with hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Dietary diversity as a sustainable approach towards micronutrient deficiencies in India.The Indian journal of medical research · 2022Review
- Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes.JAMA network open · 2022Article
- Associations of Serum and Red Blood Cell Folate With All-Cause and Cardiovascular Mortality Among Hypertensive Patients With Elevated Homocysteine.Frontiers in nutrition · 2022Article
- Development and validation using NHANES data of a predictive model for depression risk in myocardial infarction survivors.Heliyon · 2022Article
- Serum Folate and All-Cause Mortality is of Non-Linear Relationship Among Population with Chronic Kidney Disease: A Retrospective Cohort Study.International journal of general medicine · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA significant shift toward high folate concentrations has been taking place following the mandatory folate fortification. Yet the relationship between folate and health outcomes beyond neural tube defects remains understudied. We longitudinally examined relationships between serum folate and risk of cardiovascular death.
methodsWe analyzed data of 3116 adults aged ≥19 who participated in the Third National Health and Nutrition Examination Survey, 1991-1994 and were diagnosed with hypertension. Vital status was followed through December 31, 2010. Cox regression was used to estimate hazard ratios (HRs) of cardiovascular deaths for individuals with serum folate in the first quartile and fourth quartile compared with the patients with interquartile folate.
resultsAfter 33627 person years (p*ys) of follow-up, 1298 deaths were recorded with 638 cardiovascular disease (CVD) deaths (109 strokes and 529 heart diseases). A U-shaped association appeared after multivariable adjustment for heart disease, acute myocardial infarction, and overall CVD deaths. The mortality rate for heart disease in patients with low, moderate, and high folate were 12.18/1000 p*ys, 14.12/1000 p*ys, and 23.80/1000 p*ys, respectively, and the corresponding adjusted HRs were 1.79 (95% confidence interval, CI = 1.63-1.98), 1.00 (reference), and 1.31 (1.17-1.46). The HRs of acute myocardial infarction were 2.28 (1.80-2.88), 1.00 (reference), and 1.77 (1.42-2.20) for hypertensive patients with serum folate in low quartile, interquartile, and high quartile, respectively.
conclusionsAmong hypertensive adults, both low and high folate were associated with an elevated risk of dying from cardiovascular diseases compared with adults with moderate serum folate concentration.
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