ReviewEye (London, England)2020
The role of intracranial pressure in glaucoma and therapeutic implications.
Review in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Use of Bimatoprost Intracameral Implant for the Treatment of Glaucoma: A Focused Narrative Review.Cureus · 2026Review
- Extracellular Vesicles and Glaucoma: Opportunities and Challenges.Current eye research · 2025Review
- Swept-Source Optical Coherence Tomography Angiography for Retinal Neurovascular Structural Evaluation in a Chronic Unpredictable Mild Stress Rat Model.Translational vision science & technology · 2025Article
- Systemic Carbonic Anhydrase Inhibitors in Common Ophthalmic Diseases: A Scoping Review from A Clinical Standpoint.Current ophthalmology reports · 2025Review
- Derivation, external and clinical validation of a deep learning approach for detecting intracranial hypertension.NPJ digital medicine · 2024Article
- Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma.Investigative ophthalmology & visual science · 2024Observational
- Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve.Fluids and barriers of the CNS · 2024Article
- Derivation, External Validation and Clinical Implications of a deep learning approach for intracranial pressure estimation using non-cranial waveform measurements.medRxiv : the preprint server for health sciences · 2024Article
- The Benefit of Nocturnal IOP Reduction in Glaucoma, Including Normal Tension Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- Cell-Based Therapies for Glaucoma.Translational vision science & technology · 2023Article
- Comment on: 'Could the AREDS formula benefit patients with glaucoma?'Eye (London, England) · 2023Article
- The Relationship between Intracranial Pressure and Visual Field Zones in Normal-Tension Glaucoma Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Paving the way while playing catch up: mitochondrial genetics in African ancestry primary open-angle glaucoma.Frontiers in ophthalmology · 2023Article
- The Role of Axonal Transport in Glaucoma.International journal of molecular sciences · 2022Review
- Problems in CSF and Ophthalmic Disease Research.Frontiers in ophthalmology · 2022Review
- Hyperintense areas in the intraorbital optic nerve evaluated by T2-weighted magnetic resonance imaging: a glymphatic pathway?Surgical and radiologic anatomy : SRA · 2021Article
- White matter alterations in glaucoma and monocular blindness differ outside the visual system.Scientific reports · 2021Article
- Distribution of IOP and its relationship with refractive error and other factors: the Anyang University Students Eye Study.International journal of ophthalmology · 2021Article
- Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild Open-Angle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study.Ophthalmology and therapy · 2020Article
- [Dependency of intraocular pressure on body posture in glaucoma patients : New approaches to pathogenesis and treatment].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite glaucoma being the second leading cause of blindness globally, its pathogenesis remains incompletely understood. Although intraocular pressure (IOP) contributes to glaucoma, and reducing IOP slows progress of the disease, some patients progress despite normal IOP (NTG). Glaucomatous damage causes characteristic cupping of the optic nerve where it passes through the lamina cribrosa. There is evidence that cerebrospinal fluid (CSF) within the optic nerve sheath has a different composition from CSF surrounding the brain. Furthermore, fluctuations in CSF flow into the optic nerve sheath may be reduced by trabeculae within the sheath, and on standing intracranial pressure (ICP) within the sheath is stabilised at around 3 mmHg due to orbital pressure. Blood pressure has been linked both to glaucoma and ICP. These facts have led some to conclude that ICP does not play a role in glaucoma. However, according to stress formulae and Laplace's Law, stress within the lamina cribrosa is dependent on the forces on either side of it, (IOP and ICP), and its thickness. On lying flat at night, ICP between the brain and optic nerve sheath should equalise. Most evidence suggests ICP is lower in glaucoma than in control groups, and that the lamina cribrosa is thinner and more posteriorly displaced in glaucoma. Subjects who have had ICP reduced have developed signs of glaucoma. This review finds most evidence supports a role for low ICP in the pathogenesis of glaucoma. Caffeine, theophylline and vitamin A may increase ICP, and could be new candidates for an oral treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.