ArticleMucosal immunology2020
NK cell recruitment limits tissue damage during an enteric helminth infection.
Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Vaccination against helminth IL-33 modulators permits immune-mediated parasite ejection.Cell reports · 2025Article
- Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs.Scientific reports · 2024Article
- Toxoplasma gondii suppress human cord blood cell differentiation to the NK cell population.Immunity, inflammation and disease · 2024Article
- IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration.Nature communications · 2023Article
- The Potential Nexus between Helminths and SARS-CoV-2 Infection: A Literature Review.Journal of immunology research · 2023Review
- Disease tolerance: a protective mechanism of lung infections.Frontiers in cellular and infection microbiology · 2023Review
- Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity.The Journal of experimental medicine · 2022Article
- Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.Mucosal immunology · 2022Article
- Microbial regulation of intestinal motility provides resistance against helminth infection.Mucosal immunology · 2022Article
- Communication is key: Innate immune cells regulate host protection to helminths.Frontiers in immunology · 2022Review
- Tissue-Dependent Adaptations and Functions of Innate Lymphoid Cells.Frontiers in immunology · 2022Review
- Cytokine elevation in the mouse small intestine at the early stage of infection with the gastrointestinal parasite Heligmosomoides polygyrus.The Journal of veterinary medical science · 2021Article
- Transcriptomic Analysis of Ovine Hepatic Lymph Node FollowingFrontiers in immunology · 2021Article
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
Parasitic helminths cause significant damage as they migrate through host tissues to complete their life cycle. While chronic helminth infections are characterized by a well-described Type 2 immune response, the early, tissue-invasive stages are not well understood. Here we investigate the immune pathways activated during the early stages of Heligmosomoides polygyrus bakeri (Hpb), a natural parasitic roundworm of mice. In contrast to the Type 2 immune response present at later stages of infection, a robust Type 1 immune signature including IFNg production was dominant at the time of parasite invasion and granuloma formation. This early response was associated with an accumulation of activated Natural Killer (NK) cells, with no increase of other innate lymphoid cell populations. Parabiosis and confocal microscopy studies indicated that NK cells were recruited from circulation to the small intestine, where they surrounded parasitic larvae. NK cell recruitment required IFNγ receptor signaling, but was independent of CXCR3 expression. The depletion of tissue-infiltrating NK cells altered neither worm burden nor parasite fitness, but increased vascular injury, suggesting a role for NK cells in mediating tissue protection. Together, these data identify an unexpected role for NK cells in promoting disease tolerance during the invasive stage of an enteric helminth infection.
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Registered trials
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