Evidence map›Paper›PMID 31776390›Full record

ArticleScientific reports2019

Craniosynostosis surgery: workflow based on virtual surgical planning, intraoperative navigation and 3D printed patient-specific guides and templates.

David García-Mato, Santiago Ochandiano, Mónica García-Sevilla, Carlos Navarro-Cuéllar, Juan V Darriba-Allés, Roberto García-Leal, José A Calvo-Haro, Rubén Pérez-Mañanes, José I Salmerón, Javier Pascau

Abstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Quantitative intraoperative assessment of fronto-orbital advancement and remodelling in craniosynostosis.International journal of computer assisted radiology and surgery · 2026
    Article
  3. Article
  4. Comparison of behavioral outcomes following cranial vault remodeling versus strip craniectomy for non-syndromic sagittal craniosynostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Article
  6. Mathematical methods for assessing the accuracy of pre-planned and guided surgical osteotomies.International journal of computer assisted radiology and surgery · 2025
    Article
  7. Surgery of craniosynostosis: a historical review.Annals of medicine and surgery (2012) · 2025
    Review
  8. Article
  9. Normscan: open-source Python software to create average models from CT scans.International journal of computer assisted radiology and surgery · 2025
    Article
  10. Article
  11. The Role of Virtual Surgical Planning in Surgery for Complex Craniosynostosis.Plastic and reconstructive surgery. Global open · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Three-dimensional printing and craniosynostosis surgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Review
  18. Smartphone-assisted Augmented Reality in Craniofacial Surgery.Plastic and reconstructive surgery. Global open · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David García-MatoDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0001-5390-5768
Santiago OchandianoInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Mónica García-SevillaDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.
Carlos Navarro-CuéllarInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Juan V Darriba-AllésInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Roberto García-LealInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
José A Calvo-HaroInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Rubén Pérez-MañanesInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
José I SalmerónInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Javier PascauDepartamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain. jpascau@ing.uc3m.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Craniosynostosis must often be corrected using surgery, by which the affected bone tissue is remodeled. Nowadays, surgical reconstruction relies mostly on the subjective judgement of the surgeon to best restore normal skull shape, since remodeled bone is manually placed and fixed. Slight variations can compromise the cosmetic outcome. The objective of this study was to describe and evaluate a novel workflow for patient-specific correction of craniosynostosis based on intraoperative navigation and 3D printing. The workflow was followed in five patients with craniosynostosis. Virtual surgical planning was performed, and patient-specific cutting guides and templates were designed and manufactured. These guides and templates were used to control osteotomies and bone remodeling. An intraoperative navigation system based on optical tracking made it possible to follow preoperative virtual planning in the operating room through real-time positioning and 3D visualization. Navigation accuracy was estimated using intraoperative surface scanning as the gold-standard. An average error of 0.62 mm and 0.64 mm was obtained in the remodeled frontal region and supraorbital bar, respectively. Intraoperative navigation is an accurate and reproducible technique for correction of craniosynostosis that enables optimal translation of the preoperative plan to the operating room.

Indexed as

Printing, Three-DimensionalWorkflowBiomedical EngineeringBone RemodelingCranial SuturesCraniosynostosesFemaleHumansImaging, Three-DimensionalInfantIntraoperative PeriodMaleOsteotomyPlastic Surgery ProceduresPrecision MedicineSkull

Identifiers

PMID31776390
PMCPMC6881390

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.