ArticleScience translational medicine2019
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01764529 (Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Molecular Pathways and Circulating Biomarkers in Cerebral Cavernous Malformations-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Gut microbes in cerebrovascular diseases: Gut flora imbalance, potential impact mechanisms and promising treatment strategies.Frontiers in immunology · 2022Pooled it
- At the Intersection of Gut Microbiome and Stroke: A Systematic Review of the Literature.Frontiers in neurology · 2021Pooled it
- Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.Molecular biomedicine · 2026Review
- Article
- Identification of the adhesion GPCR ADGRL4/ELTD1 as a novel potential prognostic biomarker for cerebral cavernous malformation disease.Molecular medicine (Cambridge, Mass.) · 2026Article
- MEKK3 bridges gut-brain communication and cerebral cavernous malformation pathogenesis.Cell death discovery · 2026Review
- Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives.Journal of neurochemistry · 2026Review
- The Emerging Role of the Gut Microbiome in Cerebral Cavernous Malformation: A New Novel Therapeutic Strategy?International journal of molecular sciences · 2025Review
- Integrative multi-omics analysis identifies key genes and colocalized signals associated with colorectal cancer risk.BMC cancer · 2025Article
- Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions.Current gene therapy · 2025Article
- Except for Robust Outliers, Rapamycin Increases Lesion Burden in a Murine Model of Cerebral Cavernous Malformations.Translational stroke research · 2025Article
- Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy.Brain and behavior · 2025Review
- Review
- Pharmacological blocking of neutrophil extracellular traps attenuates immunothrombosis and neuroinflammation in cerebral cavernous malformation.Nature cardiovascular research · 2024Article
- mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis.Circulation research · 2024Article
- KRIT1 in vascular biology and beyond.Bioscience reports · 2024Review
- Peripheral macrophages in the development and progression of structural cerebrovascular pathologies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- mTORC1 Inhibitor Rapamycin Inhibits Growth of Cerebral Cavernous Malformation in Adult Mice.Stroke · 2023Article
- CmPn/CmP Signaling Networks in the Maintenance of the Blood Vessel Barrier.Journal of personalized medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors at 14 institutions in 4 countries.
Alan T TangDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0003-1422-0349
Katie R SullivanDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0003-1162-337X
Courtney C HongDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Lauren M GoddardDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Aparna MahadevanDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0001-6013-5407
Aileen RenDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.ORCID 0000-0002-1116-900X
Heidy PardoDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Amy PeiperDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-9291-5563
Erin GriffinDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-4775-4833
Ceylan TanesDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lisa M MatteiDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jisheng YangDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Li LiDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Patricia Mericko-IshizukaDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Le ShenNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.ORCID 0000-0002-4367-5476
Nicholas HobsonNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.ORCID 0000-0001-6034-8795
Romuald GirardNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.ORCID 0000-0002-5893-9315
Rhonda LightleNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Thomas MooreNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Robert ShenkarNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.ORCID 0000-0002-1300-6845
Sean P PolsterNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Claudia J RödelInstitute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.ORCID 0000-0002-2384-1537
Ning LiDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Qin ZhuGraduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-5539-6071
Kevin J WhiteheadDivision of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-0419-7309
Xiangjian ZhengDepartment of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.ORCID 0000-0001-6277-5168
Amy AkersAngioma Alliance, Norfolk, VA 23517, USA.
Leslie MorrisonDepartment of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA.ORCID 0000-0002-0092-193X
Helen KimCenter for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-1937-354X
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Christopher J LengnerDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0574-5189
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-4510-9718
Anna VelcichDepartment of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.
Leonard AugenlichtDepartment of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.ORCID 0000-0003-3027-5489
Salim Abdelilah-SeyfriedInstitute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.ORCID 0000-0003-3183-3841
Wang MinDepartment of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA.
Douglas A MarchukDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Issam A AwadNeurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Mark L KahnDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA. markkahn@pennmedicine.upenn.edu.ORCID 0000-0002-6489-7086
University of Pennsylvania · USUniversity of Chicago · USDuke University · USChildren's Hospital of Philadelphia · USAlbert Einstein College of Medicine · USUniversity of Potsdam · DEAngioma Alliance · USCalifornia Institute for Regenerative Medicine · USCentenary Institute · AUUniversity of California, San Francisco · USUniversity of Lübeck · DEUniversity of New Mexico · USUniversity of Utah · USYale University · US
Funding
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Maurizio Macaluso · 2019 to 2026
$51.2MVCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8MSomatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI MARCHUK, DOUGLAS A. · 2015 to 2024
$12.9MTRAINING GRANT IN HEMOSTASIS AND THROMBOSIST32HL007971 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Rodney M Camire · 2001 to 2026
$10.6MHeg-CCM Signaling in Cardiovascular Development and DiseaseR01HL094326 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2009 to 2018
$3.5MAge and Diet: Major interacting factors that drive sporadic intestinal cancerR01CA174432 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUGENLICHT, LEONARD H · 2014 to 2018
$3.3MTLR4 and the microbiome in CCM diseaseR01NS100949 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2017 to 2021
$2.8MNutritionally Driven Sporadic Intestinal Tumors: Impact on Stem CellsR01CA229216 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUGENLICHT, LEONARD H · 2018 to 2022
$2.4MCCM3-mediated exocytosis in pathogenesis of cerebral cavernous malformationR01HL136507 · NHLBI · YALE UNIVERSITY · PI STERN, DAVID F · 2017 to 2020
$1.9MThe molecular pathogenesis of cerebral cavernous malformationsF30NS100252 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TANG, ALAN TIEN · 2017 to 2018
$80kNCATS NIH HHS U2C TR002818NCI NIH HHS R01 CA174432NCI NIH HHS R01 CA229216NHLBI NIH HHS R01 HL094326NHLBI NIH HHS R01 HL136507NHLBI NIH HHS T32 HL007971NINDS NIH HHS F30 NS100252NINDS NIH HHS P01 NS092521NINDS NIH HHS R01 NS100949NINDS NIH HHS U54 NS065705
Abstract
Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in
Indexed as
AnimalsApoptosis Regulatory ProteinsBrainCarrier ProteinsColitisDexamethasoneDextran SulfateEndothelial CellsEpithelial CellsGastrointestinal MicrobiomeGastrointestinal TractHemangioma, Cavernous, Central Nervous SystemHumansIntestinal MucosaKRIT1 ProteinLigandsApoptosis Regulatory ProteinsCarrier ProteinsCCM2 protein, humanDexamethasoneDextran SulfateKRIT1 ProteinKRIT1 protein, humanLigandsMembrane ProteinsPDCD10 protein, humanPDCD10 protein, mouseProto-Oncogene ProteinsToll-Like Receptor 4
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT01764529ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.