Evidence map›Paper›PMID 31776285›Full record

ArticleJournal of virology2020

Astrovirus Replication Is Inhibited by Nitazoxanide

Virginia Hargest, Bridgett Sharp, Brandi Livingston, Valerie Cortez, Stacey Schultz-Cherry

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  14. Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?Journal, genetic engineering & biotechnology · 2020
    Review
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Virginia HargestDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Bridgett SharpDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Brandi LivingstonDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Valerie CortezDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA stacey.schultz-cherry@stjude.org.
St. Jude Children's Research Hospital · US

Funding

Do they or don't they: astrovirus-induced diarrheaR21AI135254 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SCHULTZ-CHERRY, STACEY L · 2018 to 2019
$561k
NIAID NIH HHS R21 AI135254
6 · The paper itself

Abstract

Astroviruses (AstV) are a leading cause of diarrhea, especially in the very young, the elderly, and immunocompromised populations. Despite their significant impact on public health, no drug therapies for astrovirus have been identified. In this study, we fill this gap in knowledge and demonstrate that the FDA-approved broad-spectrum anti-infective drug nitazoxanide (NTZ) blocks astrovirus replication

Indexed as

AnimalsAstroviridae InfectionsCaco-2 CellsCell SurvivalDiarrheaEnterocolitis, NecrotizingHumansMamastrovirusNitro CompoundsPoultryThiazolesVirus ReplicationnitazoxanideNitro CompoundsThiazolesantiviral agentsastrovirusdiarrheaviral replication

Identifiers

PMID31776285
PMCPMC7022343
OpenAlexW2990215373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.