Evidence map›Paper›PMID 31776273›Full record

ArticleJournal of virology2020

Genetic Diversity, Compartmentalization, and Age of HIV Proviruses Persisting in CD4

Bradley R Jones, Rachel L Miller, Natalie N Kinloch, Olivia Tsai, Hawley Rigsby, Hanwei Sudderuddin, Aniqa Shahid, Bruce Ganase, Chanson J Brumme, Marianne Harris and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

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  19. Review
  20. Limited HIV-1 Subtype CPathogens (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Bradley R Jones *BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Rachel L Miller *Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Natalie N KinlochBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Olivia TsaiFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Hawley RigsbyCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Hanwei SudderuddinBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Aniqa ShahidBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Bruce GanaseBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Chanson J BrummeBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Marianne HarrisBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Art F Y PoonDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, Ontario, Canada.
Mark A BrockmanBC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.ORCID 0000-0001-6432-1426
Rémi FromentinCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Nicolas ChomontCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Jeffrey B Joy *BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Zabrina L Brumme *BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada zbrumme@sfu.ca.ORCID 0000-0002-8157-1037
Simon Fraser University · CACentre Hospitalier de l’Université de Montréal · CAUniversity of British Columbia · CAAIDS Vancouver · CAWestern University · CA

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
Genetics, dynamics and fitness of the HIV-1 latent reservoirR21AI127029 · NIAID · SIMON FRASER UNIVERSITY · PI BROCKMAN, MARK ALAN, BRUMME, ZABRINA · 2018 to 2019
$300k
CIHR HB1-164063CIHR PJT-159625NIAID NIH HHS R21 AI127029NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

The HIV reservoir, which comprises diverse proviruses integrated into the genomes of infected, primarily CD4

Indexed as

Genetic VariationAdolescentAnti-Retroviral AgentsBase SequenceCD4-Positive T-LymphocytesChildDNA, ViralHIV-1HIV InfectionsHumansPhylogenyProvirusesT-Lymphocyte SubsetsViral LoadYoung AdultAnti-Retroviral AgentsDNA, ViralCD4+ T cellscell subsetscellular subsetsgenetic compartmentalizationHIVhuman immunodeficiency viruspersistenceproviral agereservoir

Identifiers

PMID31776273
PMCPMC7022348
OpenAlexW2990889228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.