Evidence map›Paper›PMID 31776261›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Polarized PtdIns(4,5)P

Takafumi Kawai, Haruhiko Miyata, Hiroki Nakanishi, Souhei Sakata, Shin Morioka, Junko Sasaki, Masahiko Watanabe, Kenji Sakimura, Toyoshi Fujimoto, Takehiko Sasaki and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Ciliary Membrane Lipid Homeostasis in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Nonsubstrate PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Andrology · 2025
    Review
  7. Article
  8. Article
  9. The sperm-specific KFrontiers in cell and developmental biology · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Interaction between S4 and the phosphatase domain mediates electrochemical coupling in voltage-sensing phosphatase (VSP).Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. The CaThe Journal of biological chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Takafumi KawaiGraduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Haruhiko MiyataResearch Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan.
Hiroki NakanishiResearch Center for Biosignal, Akita University, Akita 010-8543, Japan.
Souhei SakataGraduate School of Medicine, Osaka University, Suita 565-0871, Japan.
Shin MoriokaMedical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Junko SasakiMedical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Masahiko WatanabeGraduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.ORCID 0000-0001-5037-7138
Kenji SakimuraBrain Research Institute, Niigata University, Niigata 951-8585, Japan.
Toyoshi FujimotoGraduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.ORCID 0000-0002-3601-7977
Takehiko SasakiMedical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Suita 565-0871, Japan.ORCID 0000-0001-9859-6217
Yasushi OkamuraGraduate School of Medicine, Osaka University, Suita 565-0871, Japan; yokamura@phys2.med.osaka-u.ac.jp.ORCID 0000-0001-5386-7968
The University of Osaka · JPTokyo Medical and Dental University · JPAkita University · JPHiroshima University · JPHokkaido University · JPNagoya University · JPNiigata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The voltage-sensing phosphatase (VSP) is a unique protein that shows voltage-dependent phosphoinositide phosphatase activity. Here we report that VSP is activated in mice sperm flagellum and generates a unique subcellular distribution pattern of PtdIns(4,5)P

Indexed as

AnimalsCalcium ChannelsFlagellaIon ChannelsLarge-Conductance Calcium-Activated Potassium ChannelsMaleMembrane PotentialsMiceMice, KnockoutPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester HydrolasesSpermatozoaSperm MotilitySperm TailCalcium ChannelsIon ChannelsKcnu1 protein, mouseLarge-Conductance Calcium-Activated Potassium ChannelsPhosphatidylinositol 4,5-DiphosphatePhosphoric Monoester Hydrolasesmembrane potentialPtdIns(4,5)P2spermvoltage-sensing phosphatase

Identifiers

PMID31776261
PMCPMC6925991
OpenAlexW2991400734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.