Evidence map›Paper›PMID 31776241›Full record

ArticlemSphere2019

Siz2 Prevents Ribosomal DNA Recombination by Modulating Levels of Tof2 in Saccharomyces cerevisiae.

Neethu Maria Abraham, Kathirvel Ramalingam, Saketh Murthy, Krishnaveni Mishra

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Neethu Maria AbrahamDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Kathirvel RamalingamDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Saketh MurthyDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Krishnaveni MishraDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India krishnaveni@uohyd.ac.in.ORCID 0000-0001-7596-7863
University of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribosomal DNA (rDNA) recombination in budding yeast is regulated by multiple converging processes, including posttranslational modifications such as SUMOylation. In this study, we report that the absence of a SUMO E3 ligase, Siz2, results in increased unequal rDNA exchange. We show that Siz2 is enriched at the replication fork barrier (RFB) in the rDNA and also controls the homeostasis of Tof2 protein.

Indexed as

Gene Expression Regulation, FungalRecombination, GeneticDNA-Binding ProteinsDNA, FungalDNA, RibosomalGene DeletionGene ExpressionIntracellular Signaling Peptides and ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Binding ProteinsDNA, FungalDNA, RibosomalFOB1 protein, S cerevisiaeIntracellular Signaling Peptides and ProteinsSaccharomyces cerevisiae ProteinsSiz2 protein, S cerevisiaeTOF2 protein, S cerevisiaeFob1rDNA recombinationSiz2SUMOylationTof2Ulp2

Identifiers

PMID31776241
PMCPMC6881720
OpenAlexW2990542684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.