ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Level of Consciousness Is Dissociable from Electroencephalographic Measures of Cortical Connectivity, Slow Oscillations, and Complexity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Neural field modeling and analysis of consciousness states in the brain.Neuroscience of consciousness · 2025Article
- Time to Wake Up! The Ongoing Search for General Anesthetic Reversal Agents.Anesthesiology · 2024Article
- A systematic approach to brain dynamics: cognitive evolution theory of consciousness.Cognitive neurodynamics · 2023Article
- Feedback information transfer in the human brain reflects bistable perception in the absence of report.PLoS biology · 2023Article
- Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the frontoparietal networks.Human brain mapping · 2023Article
- Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.Communications biology · 2023Article
- Perioperative Extracellular Brain Free-Water Changes for Older Adults Electing Total Knee Arthroplasty with General versus Spinal Anesthesia: A Pilot Study.Journal of Alzheimer's disease : JAD · 2023Article
- Article
- Prefrontal cortex as a key node in arousal circuitry.Trends in neurosciences · 2022Review
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Slow waves form expanding, memory-rich mesostates steered by local excitability in fading anesthesia.iScience · 2022Article
- Ketamine and sleep modulate neural complexity dynamics in cats.The European journal of neuroscience · 2022Article
- Brain areas modulation in consciousness during sevoflurane anesthesia.Frontiers in integrative neuroscience · 2022Review
- Comatose Patients After Cardiopulmonary Resuscitation: An Analysis Based on Quantitative Methods of EEG Reactivity.Frontiers in neurology · 2022Article
- Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane.Frontiers in pharmacology · 2022Article
- Capacity for consciousness under ketamine anaesthesia is selectively associated with activity in posteromedial cortex in rats.Neuroscience of consciousness · 2022Article
- Machine learning reveals interhemispheric somatosensory coherence as indicator of anesthetic depth.Frontiers in neuroinformatics · 2022Article
- Paradoxical markers of conscious levels: Effects of propofol on patients in disorders of consciousness.Frontiers in human neuroscience · 2022Article
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8 authors.
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Abstract
Leading neuroscientific theories posit a central role for the functional integration of cortical areas in conscious states. Considerable evidence supporting this hypothesis is based on network changes during anesthesia, but it is unclear whether these changes represent state-related (conscious vs unconscious) or drug-related (anesthetic vs no anesthetic) effects. We recently demonstrated that carbachol delivery to prefrontal cortex (PFC) restored wakefulness despite continuous administration of the general anesthetic sevoflurane. By contrast, carbachol delivery to parietal cortex, or noradrenaline delivery to either prefrontal or parietal cortices, failed to restore wakefulness. Thus, carbachol-induced reversal of sevoflurane anesthesia represents a unique state that combines wakefulness with clinically relevant anesthetic concentrations in the brain. To differentiate the state-related and drug-related associations of cortical connectivity and dynamics, we analyzed the electroencephalographic data gathered from adult male Sprague Dawley rats during the aforementioned experiments for changes in functional cortical gamma connectivity (25-155 Hz), slow oscillations (0.5-1 Hz), and complexity (<175 Hz). We show that higher gamma (85-155 Hz) connectivity is decreased (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.