Evidence map›Paper›PMID 31776192›Full record

ArticleJournal of clinical microbiology2020

High Agreement Between an Ultrasensitive Clostridioides difficile Toxin Assay and a C. difficile Laboratory Algorithm Utilizing GDH-and-Toxin Enzyme Immunoassays and Cytotoxin Testing.

Marie L Landry, Jeffrey E Topal, Joel Estis, Phoebe Katzenbach, Niamh Nolan, Johanna Sandlund

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  2. Diagnosis ofJournal of medical microbiology · 2024
    Review
  3. Emerging Diagnostics inInternational journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marie L LandryDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut, USA marie.landry@yale.edu.
Jeffrey E TopalSection of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Joel EstisSingulex, Inc., Alameda, California, USA.
Phoebe KatzenbachSingulex, Inc., Alameda, California, USA.
Niamh NolanSingulex, Inc., Alameda, California, USA.
Johanna SandlundSingulex, Inc., Alameda, California, USA.
Yale New Haven Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The Singulex Clarity C. diff toxins A/B (Clarity) assay is an automated, ultrasensitive immunoassay for the detection of

Indexed as

AdultAlgorithmsAutomation, LaboratoryBacterial ProteinsBacterial ToxinsClostridioides difficileClostridium InfectionsEnterotoxinsFecesFemaleGlutamate DehydrogenaseHumansImmunoenzyme TechniquesMaleSensitivity and SpecificityBacterial ProteinsBacterial ToxinsEnterotoxinsGlutamate DehydrogenasetcdA protein, Clostridium difficiletoxB protein, Clostridium difficileCDIC. difficileC. difficile EIAC. difficile PCRcytotoxinsingle-molecule countingtoxinultrasensitive

Identifiers

PMID31776192
PMCPMC6989068
OpenAlexW2990215024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.