Evidence map›Paper›PMID 31776129›Full record

ArticleCold Spring Harbor molecular case studies2020

Dramatic increase in gene mutational burden after transformation of follicular lymphoma into TdT

Jonathan P Belman, Wenzhao Meng, Hong Yi Wang, Jie Li, Honore T Strauser, Aaron M Rosenfeld, Qian Zhang, Eline T Luning Prak, Mariusz Wasik

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jonathan P BelmanHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Wenzhao MengHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Hong Yi WangHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Jie LiFox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Honore T StrauserHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Aaron M RosenfeldHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Qian ZhangHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Eline T Luning PrakHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Mariusz WasikHospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Hospital of the University of Pennsylvania · USFox Chase Cancer Center · US

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SHELLEY L BERGER · 1985 to 2026
$222.3M
TRANSFUSION MEDICINE RESEARCH TRAINING PROGRAMT32HL007775 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SIEGEL, DONALD LAWRENCE · 1993 to 2023
$2.8M
NCI NIH HHS P30 CA016520NHLBI NIH HHS T32 HL007775
6 · The paper itself

Abstract

Transformation of follicular lymphoma (FL) into B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) is rare and results in greatly increased aggressiveness of clinical course. Here we present extensive molecular analysis of this unusual transformation, including immunoglobulin (Ig) gene rearrangement studies, cytogenetic analysis, and whole-exome sequencing (WES) of the patient's FL, B-ALL/LBL, and normal cells. Although FL showed marked somatic hypermutation (SHM) of the Ig genes, SHM appeared to be even more extensive in B-ALL/LBL. Cytogenetically, at least three translocations were identified in the B-ALL/LBL involving the

Indexed as

Biomarkers, TumorMutationAdultAllelesAmino Acid SequenceBase SequenceBiopsyCell Transformation, NeoplasticChromobox Protein Homolog 5Diagnostic ImagingDisease ProgressionExome SequencingGene RearrangementHistonesHumansImmunoglobulin Heavy ChainsBiomarkers, TumorCBX1 protein, humanChromobox Protein Homolog 5HistonesImmunoglobulin Heavy Chainshematological neoplasm

Identifiers

PMID31776129
PMCPMC6996523
OpenAlexW2989852203

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.