Evidence map›Paper›PMID 31775875›Full record

ArticleClinical epigenetics2019

Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood.

Roy Lardenoije, Janou A Y Roubroeks, Ehsan Pishva, Markus Leber, Holger Wagner, Artemis Iatrou, Adam R Smith, Rebecca G Smith, Lars M T Eijssen, Luca Kleineidam and 19 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  6. Article
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  9. Delineating blood DNA methylation biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 11 institutions in 8 countries.

Roy LardenoijeSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Janou A Y RoubroeksSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Ehsan PishvaSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Markus LeberDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937, Cologne, Germany.
Holger WagnerDepartment of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.
Artemis IatrouSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Adam R SmithUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Rebecca G SmithUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Lars M T EijssenSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Luca KleineidamDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937, Cologne, Germany.
Amit KawaliaDepartment of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.
Per HoffmannInstitute of Human Genetics, University of Bonn, 53127, Bonn, Germany.
Tobias LuckInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103, Leipzig, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103, Leipzig, Germany.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), 53127, Bonn, Germany.
Wolfgang MaierDepartment of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.
Michael WagnerDepartment of Neurodegeneration and Gerontopsychiatry, University of Bonn, 53127, Bonn, Germany.
René HurlemannDepartment of Psychiatry and Division of Medical Psychology, University of Bonn, 53105, Bonn, Germany.
Gunter KenisSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Muhammad AliSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Antonio Del SolLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Diego MastroeniSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Elaine DelvauxL.J. Roberts Center for Alzheimer's Research Banner Sun Health Research Institute, Sun City, AZ, USA.
Paul D ColemanL.J. Roberts Center for Alzheimer's Research Banner Sun Health Research Institute, Sun City, AZ, USA.
Jonathan MillUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Bart P F RuttenSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands.
Katie LunnonUniversity of Exeter Medical School, University of Exeter, Exeter, UK.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937, Cologne, Germany.
Daniël L A van den HoveSchool for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Maastricht University, P.O. Box 616, 6200, MD, Maastricht, the Netherlands. d.vandenhove@maastrichtuniversity.nl.
University of Bonn · DEMaastricht University · NLUniversity of Exeter · GBBanner Sun Health Research Institute · USLeipzig University · DEUniversity of Cologne · DECIC bioGUNE · ESKing's College London · GBLife & Brain (Germany) · DEUniversity of Luxembourg · LUUniversity of Würzburg · DE

Funding

Medical Research Council MR/N027973/1
6 · The paper itself

Abstract

backgroundLate-onset Alzheimer's disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present study investigated epigenome-wide patterns of DNA methylation (5-methylcytosine, 5mC) and hydroxymethylation (5-hydroxymethylcytosine, 5hmC), as well as the abundance of unmodified cytosine (UC), in relation to AD.

resultsWe identified epigenetic differences in AD patients (n = 45) as compared to age-matched controls (n = 35) in the middle temporal gyrus, pertaining to genomic regions close to or overlapping with genes such as OXT (- 3.76% 5mC, p

conclusionsThe implication of genome-wide significant differential methylation of OXT, encoding oxytocin, in two independent cohorts indicates it is a promising target for future studies on early biomarkers and novel therapeutic strategies in AD.

Indexed as

DNA Methylation5-MethylcytosineAgedAged, 80 and overAge of OnsetAlzheimer DiseaseBrain ChemistryDisease ProgressionEpigenesis, GeneticFemaleHumansIntracellular Signaling Peptides and ProteinsMaleOxytocinReceptors, NicotinicTemporal Lobe5-hydroxymethylcytosine5-MethylcytosineCHRNB1 protein, humanIntracellular Signaling Peptides and ProteinsOxytocinReceptors, NicotinicRHBDF2 protein, humanAlzheimer’s diseaseBloodBrainDNA hydroxymethylationDNA methylationEpigeneticsMiddle temporal gyrus

Identifiers

PMID31775875
PMCPMC6880587
OpenAlexW2991469415

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.