Evidence map›Paper›PMID 31775803›Full record

Observational studyJournal of cardiothoracic surgery2019

Dual antiplatelet therapy up to the time of non-elective coronary artery bypass grafting with prophylactic platelet transfusion: is it safe?

Fida Charif, Righab Hamdan, Genane Youness, Ali El Zein, Mohamad Issa, Yehya Jassar, Mahmoud Younes, Mohamad Saab

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Platelet inhibitor withdrawal and outcomes after coronary artery surgery: an individual patient data meta-analysis.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Fida CharifDivision of Pulmonary Medicine, Beirut Cardiac Institute, Beirut, Lebanon.
Righab HamdanDivision of Cardiology Medicine, Beirut Cardiac Institute, Beirut, Lebanon. mdrighabh@hotmail.com.
Genane YounessDepartment of statistics, ISSAE, Cnam, Beirut, Lebanon.
Ali El ZeinDepartment of Anesthesiology, Beirut Cardiac Institute, Beirut, Lebanon.
Mohamad IssaDepartment of Anesthesiology, Beirut Cardiac Institute, Beirut, Lebanon.
Yehya JassarDepartment of Cardiovascular surgery, Beirut Cardiac Institute, Beirut, Lebanon.
Mahmoud YounesMedical research center, Beirut Cardiac Institute, Rassoul Aazam Hospital, Beirut, Lebanon.
Mohamad SaabDepartment of Cardiovascular surgery, Beirut Cardiac Institute, Beirut, Lebanon.
Orient-Institut Beirut · LBCentre d'Etudes et De Recherche en Informatique et Communications · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGuidelines suggest that patients discontinue Clopidogrel at least 5 days prior to coronary artery bypass grafting (CABG). Those with acute coronary syndrome (ACS) are at high risk for myocardial infarction (MI) if not treated with dual antiplatelet therapy (DAPT). We sought to assess pre and post-operative outcomes of patients maintained on Clopidogrel and aspirin up to the time of surgery and compare them with those on aspirin alone.

methodsFrom the cardiac surgery database, 240 patients were retrospectively registered between January and May 2017. There were 126 patients with ACS who underwent CABG on DAPT (Clopidogrel group [CG]) and 114 patients who underwent elective CABG on aspirin alone (control). The CG received intraoperative prophylactic platelet transfusion (PPT). Demographics, comorbidities, and laboratory data were prospectively entered at the time of surgery and were subsequently retrieved for analysis. Per and postoperative findings were identified and compared between both groups.

resultsThe cohort consisted of 240 patients (mean age 61 years, 81.3% were male, SD ± 9.58). Patients in the CG were younger (Median 57 vs. 63, P-value 0.001), and with male predominance (86% versus 75%, P-value 0.028). In addition, they had less prevalence for diabetes and renal failure as compared to control (P-values 0.003, and 0.005, respectively). There were no significant differences between both groups in number of vessels grafts, duration of on-pump and aortic clamp. Hematologic laboratory data had also similar baseline values. The CG had similar bleeding rate, redo surgery and in-hospital death (P-values non-significant), however more infection and total hospital stay as compared to control (p-values 0.048 and 0.001).

conclusionPatients who are at increased risk for MI can be maintained on DAPT up to the time of CABG because surgery is safe when patients are offered PPT.

Indexed as

Coronary Artery BypassPlatelet TransfusionAcute Coronary SyndromeAdultAgedAged, 80 and overAspirinClopidogrelCombined Modality TherapyDrug Administration ScheduleDual Anti-Platelet TherapyFemaleHumansMaleMiddle AgedMyocardial InfarctionAspirinClopidogrelPlatelet Aggregation InhibitorsACSAspirineCABGClopidogrelPlatelet transfusion

Identifiers

PMID31775803
PMCPMC6880414
OpenAlexW2989825180

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.