Evidence map›Paper›PMID 31775793›Full record

ArticleVirology journal2019

First evidence of a new simian adenovirus clustering with Human mastadenovirus F viruses.

Christian E Lange, Fabien R Niama, Kenneth Cameron, Sarah H Olson, Rock Aime Nina, Alain Ondzie, Gerard Bounga, Brett R Smith, Jasmine Pante, Patricia Reed and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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  11. Non-Human Primate-Derived Adenoviruses for Future Use as Oncolytic Agents?International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Christian E LangeMetabiota Inc, Nanaimo, BC, Canada. clange_virology@gmx.de.
Fabien R NiamaNational Laboratory of Public Health, Brazzaville, Republic of the Congo.
Kenneth CameronWildlife Conversation Society, Bronx, NY, USA.
Sarah H OlsonNational Laboratory of Public Health, Brazzaville, Republic of the Congo.
Rock Aime NinaMinistry of Agriculture and Livestock, Brazzaville, Republic of the Congo.
Alain OndzieWildlife Conversation Society, Bronx, NY, USA.
Gerard BoungaWildlife Conversation Society, Bronx, NY, USA.
Brett R SmithOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA, USA.
Jasmine PanteOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA, USA.
Patricia ReedWildlife Conversation Society, Bronx, NY, USA.
Ubald TamufeMetabiota Inc, Nanaimo, BC, Canada.
Anne LaudisoitEcoHealth Alliance, New York, NY, USA.
Tracey GoldsteinOne Health Institute, School of Veterinary Medicine, University of California, Davis, CA, USA.
Romain Bagamboula MPassiMinistry of National Defense, Brazzaville, Republic of the Congo.
Damien O JolyWildlife Conversation Society, Bronx, NY, USA.
Wildlife Conservation Society · USLaboratoire National de Santé Publique du Congo · CGUniversity of California, Davis · USEcoHealth Alliance · USMinistry of Environment · CAWildlife Conservation Society Congo · CG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdenoviruses play an important role as human pathogens, though most infections are believed to be asymptomatic. The over 100 human adenovirus types are classified into seven species (A-G), some of which include simian adenoviruses. Recent findings have highlighted that simian adenoviruses have a zoonotic potential and that some human adenoviruses are likely the result of relatively recent spillover events.

methodsIn order to evaluate the risks associated with primates hunted and sold as bushmeat, multiple samples from 24 freshly killed monkeys were collected in the Republic of the Congo and tested for adenovirus DNA by PCRs targeting the conserved DNA polymerase and hexon genes.

resultsThe DNA of a novel simian adenovirus was detected in a moustached monkey (Cercopithecus cephus) by the DNA polymerase PCR, but not by the hexon PCR. The 275 nucleotide amplicon was most closely related to members of the Human mastadenovirus F species (93% HAdV-40 and 89% HAdV-41 amino acid identity), rather than to other known simian adenoviruses.

conclusionsThe phylogenetic clustering with Human mastadenovirus F sequences suggests a common ancestor, more recent than the last common ancestor of humans and moustached monkeys. The findings increase concerns about the zoonotic potential of simian adenoviruses and highlight the need for more research and surveillance on the issue.

Indexed as

Adenoviridae InfectionsAdenoviruses, HumanAdenoviruses, SimianAnimalsCapsid ProteinsCercopithecusCluster AnalysisCongoDNA, ViralMonkey DiseasesPhylogenyPolymerase Chain ReactionCapsid ProteinsDNA, Viralhexon capsid protein, AdenovirusAdenovirusAfricaBushmeatEvolutionPrimateZoonosis

Identifiers

PMID31775793
PMCPMC6880561
OpenAlexW2991018766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.