Evidence map›Paper›PMID 31775749›Full record

ArticleCardiovascular diabetology2019

Effect of beta blocker use and type on hypoglycemia risk among hospitalized insulin requiring patients.

Kathleen Dungan, Jennifer Merrill, Clarine Long, Philip Binkley

Open access · goldAbstract readComparative Study
In one paragraph

Article in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  8. The Hypoglycemic Fear Syndrome: Understanding and Addressing This Common Clinical Problem in Adults With Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2023
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kathleen DunganDivision of Endocrinology, Diabetes & Metabolism, The Ohio State University, 5th Floor McCampbell Hall, 1581 Dodd Drive, Columbus, OH, 43210-1296, USA. Kathleen.dungan@osumc.edu.
Jennifer MerrillDivision of Endocrinology, Duke University, 30 Duke Medicine Circle, Durham, NC, 22710, USA.
Clarine LongThe Ohio State University College of Medicine, 370 W. 9th Ave, Columbus, OH, 43210, USA.
Philip BinkleyDivision of Cardiovascular Medicine, The Ohio State University, 452 W. 10th Ave, Columbus, OH, 43210, USA.
The Ohio State University · USDuke University · US

Funding

The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070
6 · The paper itself

Abstract

backgroundAlthough beta blockers could increase the risk of hypoglycemia, the difference between subtypes on hypoglycemia and mortality have not been studied. This study sought to determine the relationship between type of beta blocker and incidence of hypoglycemia and mortality in hospitalized patients.

methodsWe retrospectively identified non-critically ill hospitalized insulin requiring patients who were undergoing bedside glucose monitoring and received either carvedilol or a selective beta blocker (metoprolol or atenolol). Patients receiving other beta blockers were excluded. Hypoglycemia was defined as any glucose < 3.9 mmol/L within 24 h of admission (Hypo

resultsThere were 1020 patients on carvedilol, 886 on selective beta blockers, and 10,216 on no beta blocker at admission. After controlling for other variables, the odds of Hypo

conclusionsBeta blocker use is associated with increased odds of hypoglycemia among hospitalized patients not requiring basal insulin, and odds are greater for selective beta blockers than for carvedilol. The odds of hypoglycemia-associated mortality are increased with selective beta blocker use or nonusers but not in carvedilol users, warranting further study.

Indexed as

InpatientsPatient AdmissionAdrenergic beta-AntagonistsAgedAtenololBiomarkersBlood GlucoseCarvedilolFemaleHospital MortalityHumansHypoglycemiaHypoglycemic AgentsIncidenceInsulinMaleAdrenergic beta-AntagonistsAtenololBiomarkersBlood GlucoseCarvedilolHypoglycemic AgentsInsulinMetoprololBeta blockerDiabetes mellitusHospitalized patientsHypoglycemiaMortality

Identifiers

PMID31775749
PMCPMC6882013
OpenAlexW2989897212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.