ArticleBMC infectious diseases2019
Imported cases of Chikungunya virus in Iran.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Evaluating the burden and transmission dynamics of chikungunya virus infections in the Eastern Mediterranean Region: a systematic review and meta-analysis.European journal of public health · 2025Pooled it
- Investigation of chikungunya arbovirus in cities of Bushehr province: An ELISA-based cross-sectional study.Virus research · 2026Article
- Distribution of Aedes aegypti and Aedes albopictus, and the current situation of dengue fever and chikungunya in Iran and neighboring countries: a review study.PLoS neglected tropical diseases · 2026Review
- Prevalence of Chikungunya, Dengue, and West Nile arboviruses in Iran based on enzyme-linked immunosorbent assay (ELISA): A systematic review and meta-analysis.Global epidemiology · 2025Article
- Dengue and chikungunya viruses among febrile travelers entering Iran (2015-2021): Evidence of multiple introductions from different countries.IJID regions · 2025Article
- Extensive surveillance of mosquitoes and molecular investigation of arboviruses in Central Iran.Annals of medicine and surgery (2012) · 2025Article
- Factors contributing to mosquito-borne disease: A systematic review in the Middle East and North Africa (MENA) region.Current research in parasitology & vector-borne diseases · 2025Review
- Acute Clinical Features and Persistence of Joint Pain in Probable Cases of Chikungunya Fever in Eritrea.Open access rheumatology : research and reviews · 2025Article
- A comprehensive seroepidemiology of dengue and chikungunya arboviruses in Iran, 2020-2023.Virology journal · 2024Article
- Medically Significant Vector-Borne Viral Diseases in Iran.Microorganisms · 2023Review
- Chikungunya in Zhejiang Province, Southeast China.Infectious medicine · 2023Article
- Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.Nature communications · 2023Article
- Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil.medRxiv : the preprint server for health sciences · 2023Article
- Role of Arbovirus Infection in Arthritogenic Pain Manifestation-A Systematic Review.Tropical medicine and infectious disease · 2022Review
- Epidemiological evidence of mosquito-borne viruses among persons and vectors in Iran: A study from North to South.Virologica Sinica · 2022Article
- Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries.Journal of biomedical science · 2021Review
- Article
- Pathogenic fungi infection attributes of malarial vectors Anopheles maculipennis and Anopheles superpictus in central Iran.Malaria journal · 2021Article
- Population Fluctuations and Abundance Indices of Mosquitoes (Diptera: Culicid), as the Potential Bridge Vectors of Pathogens to Humans and Animals in Mazandaran Province, Northern Iran.Journal of arthropod-borne diseases · 2021Article
- Fauna and Larval Habitat Characteristics of Mosquitoes (Diptera: Culicidae) in Kashan County, Central Iran, 2019.Journal of arthropod-borne diseases · 2021Article
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChikungunya virus (CHIKV) is a widespread mosquito-borne virus representing a serious challenge to public health. The largest outbreak in the Middle-East was recorded in 2016-2017 in Pakistan. Sistan and Baluchistan Province of Iran shares a wide border with Pakistan; accordingly, introduction of CHIKV from Pakistan to Iran seems to be probable. The current study is aimed at investigating CHIKV infection in Sistan and Baluchistan Province.
methodsBetween April 2017 and June 2018, a total of 159 serum samples of CHIK suspected cases from 10 cities of Sistan and Baluchistan Province were tested by molecular and serological assays. Samples obtained up to 4 days after onset of illness were tested by real time PCR (n = 8). Samples collected 5-10 days after disease onset were subjected to ELISA, as well as real time PCR tests (n = 72). Samples obtained after the 10th day of disease onset were tested by only ELISA (n = 79). Phylogenetic analysis of real time PCR positive samples was carried out by sequencing of a 1014-bp region of Envelope 1 gene (E1 gene). Chi-square and independent t tests were used to evaluate the association between variables and CHIKV infection.
resultsIn total, 40 (25.1%) out of 159 samples tested positive either by real time PCR or ELISA tests.Out of 151 samples serologically analyzed, 19 (12.6%) and 28 (18.6%) cases were positive for anti-CHIKV IgM and anti-CHIKV IgG antibodies, respectively. Of 80 samples tested by real time PCR, CHIKV RNA was detected in 11 (13.7%) sera, all of them had recent travel history to Pakistan. Additionally, phylogenetic analysis of 5 samples indicated their similarity with recent isolates of Pakistan outbreak 2016-2017 belonging to Indian Ocean sub-lineage of ECSA genotype. A significant correlation between abroad travel history and CHIKV infection was observed (P < 0.001). The most common clinical symptoms included fever, arthralgia/arthritis, myalgia, headache, and chill.
conclusionsThese results present substantial evidence of CHIKV introduction to Iran from Pakistan and emphasize the need for the enhancement of surveillance system and preventive measures.
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