Evidence map›Paper›PMID 31775662›Full record

ArticleBMC medical genetics2019

Effects of factor v Leiden polymorphism on the pathogenesis and outcomes of preeclampsia.

G K Ababio, K Adu-Bonsaffoh, E Abindau, G Narh, D Tetteh, F Botchway, D Morvey, J Neequaye, I K Quaye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

G K AbabioDepartment of Medical Biochemistry, University of Ghana School of Medicine and Dentistry, P. O. Box 4236, Accra, Ghana. graceababio2002@yahoo.com.
K Adu-BonsaffohDepartment of Obstetrics and Gynecology, University of Ghana School of Medicine and Dentistry, Accra, Ghana.
E AbindauDepartment of Physiology, University of Ghana School of Medicine and Dentistry, Accra, Ghana.
G NarhDepartment of Biochemistry, University of Ghana, Accra, Ghana.
D TettehNational Diabetic Research Lab, Korle-Bu Teaching Hospital, Accra, Ghana.
F BotchwayDepartment of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana.
D MorveyClinical Documentation Improvement Specialist, Southern California Hospital, Culver City, CA, 90232, USA.
J NeequayeBiochemistry, Kwame Nkrumah University of Science And Technology, Kumasi, Ghana.
I K QuayeDepartment of Applied Health Sciences, Regent University of Science and Technology, Accra, Ghana.
University of Ghana · GHKorle Bu Teaching Hospital · GHKwame Nkrumah University of Science and Technology · GHRegent University College of Science and Technology · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFactor V Leiden polymorphism is a well-recognized genetic factor in the etiology of preeclampsia. Considering that Ghana is recording high incidence of preeclampsia, we examined if factor V Leiden is a contributory factor to its development and pregnancy outcomes.

methodsSTROBE consensus checklist was adopted to recruit eighty-one (81) consenting subjects after ethical clearance. Subjects were followed up till delivery to obtain outcomes of PE. Routine blood chemistry and proteinuria were done on all samples. Factor V Leiden was characterized by polymerase chain reaction and restriction fragment length polymorphism (RFLP). The data was captured as protected health information (PHI) and analyzed with SPSS version 22.

resultsOverall allelic frequencies found in FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. The FVL mutation was more in PE and hypertensive patients. Increased white blood cells, increased uric acid and a three - fold increment of AST / ALT ratio was observed in PE cases when stratified by FVL exons (exon 8 and 10). Significant differences were also observed between FVL and age, systolic blood pressure (SBP), diastolic blood pressure (DBP), liver enzymes, white blood cells (wbc), hemoglobin levels.

conclusionFVL mutation allele frequency was 0.33, a first report. The mutation was associated with increased uric acid, liver enzymes and blood cell indices suggestive of acute inflammation.

Indexed as

Polymorphism, GeneticAdultFactor VFemaleGene FrequencyHumansPolymorphism, Restriction Fragment LengthPre-EclampsiaPregnancyPregnancy OutcomeFactor Vfactor V LeidenFactor VLeidenPolymerase chain reactionPreeclampsiaRestriction

Identifiers

PMID31775662
PMCPMC6882245
OpenAlexW2990878054

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.