ArticleBMC plant biology2019
Genome-wide association analysis for maize stem Cell Wall-bound Hydroxycinnamates.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 23 citations in OpenAlex.
- High-Density Genome-Wide Association Mapping Identifies Candidate Loci Associated with Maize Stalk Cell Wall Composition.Plants (Basel, Switzerland) · 2026Article
- Meta-QTL Analysis and Identification of Candidate Genes Associated with Stalk Lodging in Maize (Current issues in molecular biology · 2025Article
- Genome-Wide Association Study and Genomic Predictions for Hydroxycinnamate Concentrations in Maize Stover.Journal of agricultural and food chemistry · 2025Article
- Assessing the success of breeding maize inbred lines with contrasting diferulate concentrations.BMC plant biology · 2025Article
- Synthetic-biology approach for plant lignocellulose engineering.Plant biotechnology (Tokyo, Japan) · 2024Article
- Breeding for improved digestibility and processing of lignocellulosic biomass inFrontiers in plant science · 2024Review
- Silage maize as a potent candidate for sustainable animal husbandry development-perspectives and strategies for genetic enhancement.Frontiers in genetics · 2023Review
- β-Xylosidase SRBX1 Activity fromJournal of fungi (Basel, Switzerland) · 2022Article
- COMPILE: a GWAS computational pipeline for gene discovery in complex genomes.BMC plant biology · 2022Article
- The utility of metabolomics as a tool to inform maize biology.Plant communications · 2021Review
- Association mapping for maize stover yield and saccharification efficiency using a multiparent advanced generation intercross (MAGIC) population.Scientific reports · 2021Article
- Responses of Maize Internode to Water Deficit Are Different at the Biochemical and Histological Levels.Frontiers in plant science · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe structural reinforcement of cell walls by hydroxycinnamates has a significant role in defense against pests and pathogens, but it also interferes with forage digestibility and biofuel production. Elucidation of maize genetic variations that contribute to variation for stem hydroxycinnamate content could simplify breeding for cell wall strengthening by using markers linked to the most favorable genetic variants in marker-assisted selection or genomic selection approaches.
resultsA genome-wide association study was conducted using a subset of 282 inbred lines from a maize diversity panel to identify single nucleotide polymorphisms (SNPs) associated with stem cell wall hydroxycinnamate content. A total of 5, 8, and 2 SNPs were identified as significantly associated to p-coumarate, ferulate, and total diferulate concentrations, respectively in the maize pith. Attending to particular diferulate isomers, 3, 6, 1 and 2 SNPs were related to 8-O-4 diferulate, 5-5 diferulate, 8-5 diferulate and 8-5 linear diferulate contents, respectively. This study has the advantage of being done with direct biochemical determinations instead of using estimates based on Near-infrared spectroscopy (NIRS) predictions. In addition, novel genomic regions involved in hydroxycinnamate content were found, such as those in bins 1.06 (for FA), 4.01 (for PCA and FA), 5.04 (for FA), 8.05 (for PCA), and 10.03 and 3.06 (for DFAT and some dimers).
conclusionsThe effect of individual SNPs significantly associated with stem hydroxycinnamate content was low, explaining a low percentage of total phenotypic variability (7 to 10%). Nevertheless, we spotlighted new genomic regions associated with the accumulation of cell-wall-bound hydroxycinnamic acids in the maize stem, and genes involved in cell wall modulation in response to biotic and abiotic stresses have been proposed as candidate genes for those quantitative trait loci (QTL). In addition, we cannot rule out that uncharacterized genes linked to significant SNPs could be implicated in dimer formation and arobinoxylan feruloylation because genes involved in those processes have been poorly characterized. Overall, genomic selection considering markers distributed throughout the whole genome seems to be a more appropriate breeding strategy than marker-assisted selection focused in markers linked to QTL.
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